DECREASE IN BLOOD HISTAMINE IN DRUG-TREATED PARKINSONIAN-PATIENTS
DECREASE IN BLOOD HISTAMINE IN DRUG-TREATED PARKINSONIAN-PATIENTS
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DOI：
10.1007/bf03159928
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发表时间：
1991-04-01
期刊：
影响因子：
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通讯作者：
MANSO, CF
中科院分区：
文献类型：
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作者：
COELHO, MH;SILVA, IJ;MANSO, CF
测定了一组帕金森病患者（PD）和一组健康对照者的血组胺和血清组胺酶活性。未经治疗的PD患者的血组胺明显高于正常对照。左旋多巴+心多巴治疗可显著降低血组胺。当抗胆碱能药物加入到治疗中时，这种减少变得更加突出。血浆组胺酶未见明显变化。作者提出，作为一种假设，中枢神经系统有助于血液组胺浓度，其上升是神经元破坏增加的结果。
Blood histamine and serum histaminase activity were determined in a group of patients with Parkinson disease (PD) and in a group of healthy controls. Untreated PD patients present significantly higher blood histamine than normal controls.Therapy with L-dopa + cardidopa results in a significant decrease in blood histamine. This decrease becomes more accentuated when anticholinergics are added to this therapy.No significant changes were detected in plasma histaminase. The authors suggest, as a hypothesis, that the CNS contributes to blood histamine concentration and that its rise is the result of increased neuronal destruction.