Differential effects of active versus passive coping on secretory immunity
Differential effects of active versus passive coping on secretory immunity
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DOI：
10.1017/s0048577201000488
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发表时间：
2001-09-01
期刊：
影响因子：
3.7
通讯作者：
Amerongen, AVN
中科院分区：
文献类型：
--
作者：
Bosch, JA;De Geus, EJC;Amerongen, AVN
这项研究考察了两种实验室应激源的急性免疫学效应，这两种应激源预计会引起心脏自主神经活动的不同模式；即一种是“主动应对”的时间步调记忆测试，另一种是显示外科手术的“被动应对”应激视频。测定唾液S免疫球蛋白A、免疫球蛋白A亚类(免疫球蛋白A_1、免疫球蛋白A_2)和分泌成分(SC)。SC负责S-免疫球蛋白A在上皮细胞的转运，是S-免疫球蛋白A分泌的决定步骤。32名男性本科生同时接受了压力源和对照视频(一个教育电视节目)。记忆测试引发了一种典型的“战斗-逃跑”反应，特征是心率和血压增加，心脏射血前期(PEP)和迷走神经张力减少。这段手术视频产生了一种“保护-撤退”式的反应，其特征是迷走神经张力增强，心率减慢，交感神经适度协同激活(如PEP缩短和收缩压增加所示)。记忆测验引起S-Ig A、Ig A 1和Sc的浓度增加，而输出增加的程度较小。对免疫球蛋白A_2的产量无明显影响。对于手术视频，出现了不同的模式：在应激源暴露期间，在SC产量小幅增加的背景下，S-IgA保持不受影响。然而。手术录像拍摄后10min，S-Ig A水平下降。S-Ig A的下降与Ig A1的下降平行，但不是Ig A 2的下降。我们得出结论，急性应激对分泌性免疫，特别是IgA1亚类既有增强作用，也有抑制作用。这些不同反应背后的机制可能包括应激源特定的自主神经激活模式。
This study examined the acute immunological effects of two laboratory stressors, expected to evoke distinct patterns of cardiac autonomic activity; namely an "active coping" time-paced memory test, and a "passive coping" stressful video showing surgical operations. We measured salivary S-IgA, IgA-subclasses (IgA1, IgA2), and secretory component (SC). SC is responsible for the transport of S-IgA across the epithelium, and thus a rate-determining step in S-IgA secretion. Thirty-two male undergraduates were subjected to both stressors and a control video (a didactic television program). The memory test induced a typical "fight-flight" response, characterized by increases in heart rate and blood pressure in association with a decrease in cardiac preejection period (PEP) and vagal tone. The surgical video produced a "conservation-withdrawal"-like response, characterized by an enhanced vagal tone, a decrease in heart rate, and a moderate sympathetic coactivation (as indicated by a shortened PEP and an increased systolic pressure). The memory test induced an increase in the concentration and, to a lesser extent, in the output of S-IgA, IgA1, and SC. The output of IgA2 was not significantly affected. For the surgical video, a different pattern emerged: During stressor exposure S-IgA remained unaffected, against the background of a small increase in SC output. However. 10 min after the surgical video S-IgA levels had decreased. This decrease in S-IgA was paralleled by a decrease in IgA1, but not IgA2. We conclude that acute stress can have both enhancing and suppressive effects on secretory immunity, the IgA1 Subclass in particular. The mechanisms that underlie these divergent responses may include stressor-specific patterns of autonomic activation.