Soluble immune markers in the different phases of chronic hepatitis B virus infection
Soluble immune markers in the different phases of chronic hepatitis B virus infection
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DOI：
10.1038/s41598-019-50729-5
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发表时间：
2019-10-01
影响因子：
4.6
通讯作者：
Cornberg, Markus
中科院分区：
文献类型：
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作者：
Wiegand, Steffen B.;Beggel, Bastian;Cornberg, Markus
慢性B型肝炎病毒（HBV）感染可分为四个不同的连续阶段，这四个阶段由病毒学和生化标志物定义，在预后和抗病毒治疗需求方面有所不同。目前，免疫标志物反映的宿主反应不在此定义中考虑。本研究旨在探讨慢性HBV感染不同阶段的可溶性免疫标志物及其分布。在这项横断面回顾性研究中，我们调查了333例慢性HBV感染患者的14种可溶性免疫标志物（SIM），包括CXCL 10。在一小组HBeAg阳性患者中，我们分析了HBeAg血清转换前后的SIM，并将血清转换者与结果未知的患者进行了比较。在慢性HBV感染的四个阶段之间的几个SIM水平的显着差异被记录。在所有研究的SIM中，观察到CXCL 10浓度的最显著差异，肝炎患者的CXCL 10浓度最高。TGF-β和IL-17在HBeAg阴性患者中的水平不同。HBeAg阳性的HBeAg血清转换患者在血清转换前IL-12水平高于随访未知的HBeAg阳性患者。SIM如CXCL 10以及IL-12、TGF-β和IL-17可能是进一步表征慢性HBV感染阶段的有用标志物。
Chronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral treatment. Currently, host responses reflected by immune markers are not considered in this definition. We aimed to study soluble immune markers and their distribution in different phases of chronic HBV infection. In this cross-sectional retrospective study, we investigated a panel of 14 soluble immune markers (SIM) including CXCL10 in 333 patients with chronic HBV infection. In a small cohort of HBeAg positive patients we analyzed SIM before and after HBeAg seroconversion and compared seroconverters to patients with unknown outcome. Significant differences were documented in the levels of several SIM between the four phases of chronic HBV infection. The most pronounced difference among all investigated SIM was observed for CXCL10 concentrations with highest levels in patients with hepatitis. TGF-beta and IL-17 revealed different levels between HBeAg negative patients. HBeAg positive patients with HBeAg seroconversion presented higher amounts of IL-12 before seroconversion compared to HBeAg positive patients with unknown follow up. SIM such as CXCL10 but also IL-12, TGF-beta and IL-17 may be useful markers to further characterize the phase of chronic HBV infection.