Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese
Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese
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DOI：
10.5551/jat.943
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发表时间：
2009-10-01
影响因子：
4.4
通讯作者：
Takehara, Tadamichi
中科院分区：
文献类型：
--
作者：
Torisu, Takehiro;Takata, Yutaka;Takehara, Tadamichi
目的：幽门螺杆菌（Helicobacter pylori，HP）是心血管和动脉粥样硬化性疾病的危险因子.由脉搏波速度（PWV）或心踝血管指数（CAVI）确定的动脉硬度已被证明是HP阳性受试者高于HP阴性受试者;然而，这一结果仅在年轻受试者中观察到。本研究的目的是探讨中年受试者HP感染与PWV或CAVI之间可能存在的相关性。方法：我们测量了343名60岁或65岁受试者的臂踝PWV（baPWV）、CAVI、代谢标志物、胃蛋白酶原（PGs）和HP IgG抗体。结果：在校正可能的混杂因素后，萎缩性胃炎（AG）阳性组baPWV和CAVI仍显著高于AG阴性组（baPWVc; 16.63 ± 3.50 vs. 15.59 ± 3.47 p=0.010，CAVIc; 8.59 ± 1.20 vs. 8.27 ± 1.19 p=0.022）。HP阳性组baPWV和CAVI值有高于HP阴性组的趋势。AG阳性组的高密度脂蛋白胆固醇（HDL）水平和脂联素水平低于AG阴性组。结论：中年人萎缩性胃炎与动脉粥样硬化可能存在相关性。
Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects.Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs.Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63 +/- 3.50 vs. 15.59 +/- 3.47 p=0.010, CAVIc; 8.59 +/- 1.20 vs. 8.27 +/- 1.19 p=0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group.Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middle-aged subjects.