Decrease of subcutaneous adipose tissue lipolysis after exposure to hypoxia during a simulated ascent of Mt Everest
Decrease of subcutaneous adipose tissue lipolysis after exposure to hypoxia during a simulated ascent of Mt Everest
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DOI：
10.1007/s004240051137
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发表时间：
1999-12-01
影响因子：
4.5
通讯作者：
Revière, D
中科院分区：
文献类型：
--
作者：
de Glisezinski, I;Crampes, F;Revière, D
本研究的目的是检查长期缺氧对脂肪组织脂解的影响，与通常在高海拔观察到的体重减轻有关。8名男性受试者在减压舱中暴露于逐渐增加的低压缺氧31天，直到相当于海拔8848 m（Mt珠峰），在4350 m进行海拔预习服7天后。在低氧暴露之前和之后进行皮下脂肪组织的活组织检查，以研究脂肪组织敏感性的体外变化。脂肪质量，脂肪细胞体积和自发脂解不受缺氧暴露。体外脂解反应对肾上腺素、异丙肾上腺素、生长激素（GH）和甲状旁腺素（PTH）的反应明显降低（P
The purpose of this study was to examine the effects of prolonged hypoxia on adipose tissue lipolysis, in relation to the weight loss usually observed at high altitude. Eight male subjects were exposed for 31 days to gradually increasing hypobaric hypoxia up to the equivalent altitude of 8848 m (Mt Everest) in a decompression chamber, after 7 days at 4350 m for altitude pre-acclimatization. A biopsy of subcutaneous adipose tissue was performed before and after hypoxic exposure, to study in vitro changes in adipose tissue sensitivity. Fat mass, adipocyte volume and spontaneous lipolysis were not impaired by the exposure to hypoxia. The in vitro lipolytic response to epinephrine, isoproterenol, growth hormone (GH) and parathormone (PTH) decreased significantly (P