Yeast cell morphology and sexual reproduction - A short overview and some considerations
Yeast cell morphology and sexual reproduction - A short overview and some considerations
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DOI：
10.1016/j.crvi.2011.05.007
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发表时间：
2011-08-01
影响因子：
2
通讯作者：
Knop, Michael
中科院分区：
文献类型：
--
作者：
Knop, Michael
几十年来，生命科学的基础研究从小型单细胞真菌酿酒酵母的研究中获益匪浅。这种酵母被证明是识别和理解所有真核细胞基本功能的分子机制的关键。这些包括但不限于细胞繁殖（细胞周期控制）、细胞形态发生（细胞极性、细胞骨架和膜运输）和细胞信息管理（染色体生物学、转录和翻译）背后的调控机制。快速获得许多酵母物种的基因组信息，结合生物信息学分析，提供了酵母的进化历史及其成分的分子祖先的信息。这些生物体的实验程序的全面列表的可用性现在提供了一个独特的机会，了解分子过程的变化在进化的规模。酵母细胞形态是另一个有趣的因素，因为细胞形状影响与环境的相互作用。在这篇综述文章中，我提供了酵母细胞形态学的相关方面的简短总结，特别是与最具影响力的过程之一，交配和减数分裂的细胞繁殖有关。(C)2011年，科学院。由Elsevier Masson SAS出版。All rights reserved.
Over the decades, basic research in life sciences has profited greatly from the study of the small unicellular fungal species Saccharomyces cerevisiae. This yeast turned out to be key for the identification and understanding of molecular mechanisms that underlay the basic functions of all eukaryotic cells. These include, but are not limited to, the regulatory mechanisms behind cellular reproduction (cell cycle control), cellular morphogenesis (cell polarity, cytoskeleton and membrane trafficking) and the management of cellular information (chromosome biology, transcription and translation). Rapid access to genomic information of many yeast species, combined with bioinformatics analyses, provide information on the evolutionary history of yeasts and the molecular ancestry of their constituents. The availability of a comprehensive list of experimental procedures for these organisms presents now a unique opportunity to learn about variations of molecular processes on an evolutionary scale. Yeast cell morphology is another interesting factor, since cellular shapes influence the interactions with the environment on all levels. In this overview article I provide a short summary of the relevant aspects of yeast cell morphology, in particular in relation to one of the most influencing processes, cellular reproduction by mating and meiosis. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.