The inferior parietal lobule and recognition memory: expectancy violation or successful retrieval?
The inferior parietal lobule and recognition memory: expectancy violation or successful retrieval?
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顶下小叶和识别记忆：违反预期还是成功检索？
DOI：
10.1523/jneurosci.4225-09.2010
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发表时间：
2010-02-24
期刊：
影响因子：
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通讯作者：
Dobbins IG
中科院分区：
文献类型：
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作者：
O'Connor AR;Han S;Dobbins IG
情景识别的功能性神经影像学研究表明，与新材料相比，已学习材料的侧顶叶反应增加，通常被称为检索成功效应。利用一种新颖的记忆模拟的注意提示，我们通过在识别判断之前提供有效或无效的预期提示（例如“可能老了”）来操纵预期和实际识别证据之间的对应关系。虽然顶叶上区显示检索成功模式，但更大的顶叶下小叶（IPL）区域跟踪记忆线索的有效性（无效线索与有效线索），而没有检索成功敏感的侧顶叶区域对线索不敏感。即使正确识别的新项目不太可能触发实质性情景检索，也会出现无效的线索反应。在IPL中，虽然边缘上回和角回（SMG； AG）区域都表现出无效的信号幅度升高，但当遇到意外的旧物品时，每个区域与不同的皮层网络的结合是不同的；同样的研究对象在休息时也观察到这种连接模式。这些发现共同表明，在识别过程中，侧顶叶反应并不意味着情景内容的恢复，而是违反记忆期望的标志。第二个独立数据集证实了这一解释，表明SMG激活跟踪观察者的决策偏差，而不是他们的准确性，在非主导识别判断中激活增加。侧顶叶识别反应的期望违反解释与视觉搜索和古怪范式的文献一致，表明这些区域的损伤应该损害与记忆相关的定向行为，而不是检索本身。
Functional neuroimaging studies of episodic recognition demonstrate an increased lateral parietal response for studied versus new materials, often termed a retrieval success effect. Using a novel memory analogue of attentional cuing, we manipulated the correspondence between anticipated and actual recognition evidence by presenting valid or invalid anticipatory cues (e.g. “likely old”) prior to recognition judgments. Although a superior parietal region demonstrated the retrieval success pattern, a larger inferior parietal lobule (IPL) region tracked the validity of the memory cueing (invalid cueing > valid cueing) and no retrieval success-sensitive lateral parietal region was insensitive to cueing. The invalid cueing response occurred even for correctly identified new items unlikely to trigger substantive episodic retrieval. Within the IPL, although supramarginal and angular gyrus (SMG; AG) regions both demonstrated invalid cueing amplitude elevations, each region differentially coupled with distinct cortical networks when unexpectedly old items were encountered; a connectivity pattern also observed at rest in the same subjects. These findings jointly suggest that the lateral parietal response during recognition does not signify the recovery of episodic content, but is a marker of the violation of memory expectations. A second independent dataset confirmed this interpretation by demonstrating that SMG activation tracked the decision biases of observers, not their accuracy, with increased activation for non-dominant recognition judgments. The expectancy violation interpretation of the lateral parietal recognition response is consistent with the literature on visual search and oddball paradigms and suggests that damage to these regions should impair memory-linked orienting behavior and not retrieval per se.