RNA epigenetics and cardiovascular diseases
RNA epigenetics and cardiovascular diseases
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DOI：
10.1016/j.yjmcc.2019.03.010
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发表时间：
2019-04-01
影响因子：
5
通讯作者：
Accornero, Federica
中科院分区：
文献类型：
--
作者：
Dorn, Lisa E.;Tual-Chalot, Simon;Accornero, Federica
心血管疾病（CVD）仍然是西方世界的主要死亡原因。尽管在预防和管理CVD方面取得了进展，但RNA表观遗传学在心血管系统中的作用直到最近才被探索。RNA修饰的研究领域迅速扩大，在哺乳动物细胞中引入了一个新的基因调控层。RNA修饰可以控制RNA代谢的各个方面，他们的研究揭示了以前未被认识到的可能在转录后水平决定基因表达的调控途径。了解RNA修饰在CVD中的作用可能会导致更好地理解疾病机制和开发新的生物标志物或治疗策略。在这篇综述中，我们重点介绍了与心血管领域相关的RNA甲基化和腺苷至肌苷RNA编辑领域的最新和主要报告，并讨论了这一突破将如何推动精准医学领域的发展。
Cardiovascular disease (CVD) remains the leading cause of death in the Western world. Despite advances in the prevention and in the management of CVD, the role of RNA epigenetics in the cardiovascular system has been until recently unexplored. The rapidly expanding research field of RNA modifications has introduced a novel layer of gene regulation in mammalian cells. RNA modifications may control all aspects of RNA metabolism, and their study reveals previously unrecognized regulatory pathways that may determine gene expression at a post-transcriptional level. Understanding the role of RNA modifications in CVD may lead towards a better understanding of disease mechanisms and the development of novel biomarkers or therapeutic strategies. In this review, we highlight the most recent and major reports in the field of RNA methylation and adenosine to inosine RNA editing related to the cardiovascular field and we discuss how this breakthrough will advance the field of precision medicine.