Normal postprandial lipemia in men with low plasma HDL concentrations.
Normal postprandial lipemia in men with low plasma HDL concentrations.
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血浆 HDL 浓度低的男性正常餐后脂血症。
DOI：
10.1161/01.atv.12.8.972
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Grundy,SM
中科院分区：
文献类型：
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作者：
Cohen,JC;Grundy,SM
为了研究餐后脂血症与高密度脂蛋白（HDL）浓度之间的关系，我们测量了1）25名低HDL胆固醇浓度的男性的血浆甘油三酯和棕榈酸视黄酯对50克脂肪餐的反应（低于36 mg.dl-1）和正常空腹甘油三酯浓度，2）25例HDL胆固醇正常（大于40 mg·dl-1）和空腹甘油三酯浓度正常的男性，和3）20例轻度至中度空腹高甘油三酯血症（250-347 mg·dl-1）的男性。高脂血症男性（593 +/- 311 mg.dl-1.8 hr）中由脂肪餐诱导的餐后脂血症的平均幅度明显高于任何一个正常脂血症组。在HDL胆固醇水平低的高脂血症正常男性中，平均餐后脂血症（303 +/- 158 mg.dl-1.8 hr）与HDL正常男性的相应值（283 +/- 130 mg.dl-1.8 hr）相似。反映乳糜微粒残留代谢的餐后血浆棕榈酸视黄酯浓度在正常HDL组和低HDL组也相似。这些数据表明，乳糜微粒-甘油三酯清除缺陷引起过量餐后脂血是不是一个常见的发生在血脂正常的男性低HDL胆固醇浓度。因此，在本研究中，在血胆固醇正常的男性中测得的低HDL胆固醇浓度必须归因于除夸大的餐后脂血症以外的因素。
To examine the relation between postprandial lipemia and high density lipoprotein (HDL) concentrations, we measured the plasma triglyceride and retinyl palmitate responses to 50-g fat meals of 1) 25 men with low HDL cholesterol concentrations (less than 36 mg.dl-1) and normal fasting triglyceride concentrations, 2) 25 men with normal HDL cholesterol (greater than 40 mg.dl-1) and normal fasting triglyceride concentrations, and 3) 20 men with mild to moderate fasting hypertriglyceridemia (250-347 mg.dl-1). The average magnitude of postprandial lipemia induced by the fat meals was markedly higher in the hypertriglyceridemic men (593 +/- 311 mg.dl-1.8 hr) than in either of the normolipidemic groups. In normotriglyceridemic men with low HDL cholesterol, mean postprandial lipemia (303 +/- 158 mg.dl-1.8 hr) was similar to the corresponding value of men with normal HDL (283 +/- 130 mg.dl-1.8 hr). Postprandial plasma retinyl palmitate concentrations, which reflect chylomicron remnant metabolism, also were similar in normal-HDL and low-HDL groups. These data suggest that defects in chylomicron-triglyceride clearance that give rise to excess postprandial lipemia are not a common occurrence in normolipidemic men with low HDL cholesterol concentrations. Accordingly, the low HDL cholesterol concentrations measured in the normotriglyceridemic men in this study must be attributable to factors other than an exaggerated postprandial lipemia.