Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands.
Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands.
复制标题
5-HT2 受体的信号转导：受体与配体复合的三维模型的分子动力学模拟的机制假设。
DOI：
10.1021/jm00059a021
复制
发表时间：
1993
影响因子：
7.3
通讯作者：
Weinstein,H
中科院分区：
文献类型：
--
作者：
Zhang,D;Weinstein,H
The use of new methods in molecular biologyand cell physiology to elucidate the primary structures and physiological functions of cell surface receptors coupled to guanine nucleotide-binding regulatory proteins, the GPCRs, 1-8 has engendered much optimism toward prospects for the design of ligands and modulators of these receptors for therapeutic purposes. 9* 13 A key element in these prospects is the development of a three-dimensional (3-D) structural basis for the design efforts. Indeed, such 3-D models were constructed for several GPCRs from their sequences. 14* 19 The construction of molecular models ofGPCR based on perceived homologies and analogies with bacteriorhodopsin (BR) 20· 21 for which the structure is known to consist of seven transmembrane helices (TMH) linked by intracellular and extracellular loops22 presents some conceptual and practical limitations. 23· 24 In spite of such difficulties, the models can suggest hypotheses concerning modes of ligand binding that can be further
