Renal hyporesponsiveness to brain natriuretic peptide: Both generation and renal activity of cGMP are decreased in patients with pulmonary hypertension
Renal hyporesponsiveness to brain natriuretic peptide: Both generation and renal activity of cGMP are decreased in patients with pulmonary hypertension
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DOI：
10.1016/j.peptides.2006.05.023
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发表时间：
2006-11-01
期刊：
影响因子：
3
通讯作者：
Geny, Bernard
中科院分区：
文献类型：
--
作者：
Charloux, Anne;Chaouat, Ari;Geny, Bernard
我们研究了肺动脉高压 (PH) 中肾对心房和脑钠尿肽（ANP 和 BNP）的抵抗机制。与 8 名对照组相比，9 名 PH 患者的急性钠负荷排泄能力降低，尽管循环 ANP、BNP 和第二信使环磷酸鸟苷 (cGMP) 增加。患者尿cGMP/BNP 和尿钠/尿cGMP 比率降低分别表明cGMP 生成受损和肾对cGMP 反应降低。因此，PH患者对心钠肽的反应低下可能位于cGMP生成的上游和下游。利尿钠肽信号通路的破坏可能可以通过治疗来实现。 (c) 2006 Elsevier Inc. 保留所有权利。
We examined the mechanisms of renal resistance to atrial and brain natriuretic peptides (ANP and BNP) in pulmonary hypertension (PH). Compared to eight controls, nine PH patients showed a reduced ability to excrete an acute sodium load despite increased circulating ANP, BNP and cyclic guanosine monophosphate (cGMP), their second messenger. Patients' reduced urinary cGMP/BNP and natriuresis/urinary cGMP ratios demonstrated impaired generation of and reduced renal response to cGMP, respectively. Therefore, PH patients hyporesponsiveness to cardiac natriuretic peptides is likely located both upstream and downstream cGMP generation. Natriuretic peptide signalling pathway disruptions might be accessible to therapy. (c) 2006 Elsevier Inc. All rights reserved.