The quest for male germline stem cell markers: PAX7 gets ID'd.
The quest for male germline stem cell markers: PAX7 gets ID'd.
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寻找雄性生殖系干细胞标记物：PAX7 已被识别。
DOI：
10.1172/jci77926
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kumar,TRajendra
中科院分区：
文献类型：
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作者：
Kumar,TRajendra
雄性生殖系或精原干细胞（SSCs）在许多物种中是保守的，并且在长时间的生殖寿命中对精子的不间断生产至关重要。更好地了解SSC生物学为男性生殖健康，生育力保护和再生医学提供了无限的机会。尽管有几种潜在的标记物定义了精原干细胞，但并没有很多明确的标记物存在于一种罕见的精原干细胞亚群中，这些亚群能够自我更新并能够产生其他祖细胞，最终有助于精子发生的所有阶段。在2014年9月出版的JCI中，Aloisio及其同事报告说，PAX7是一种在小鼠睾丸中罕见的SSC子集中独特表达的新标记。PAX7+细胞符合真正SSC所需的所有标准。令人惊讶的是，男性生殖系特异性缺失Pax7表明它与精子发生有关。
Male germline or spermatogonial stem cells (SSCs) are conserved across many species and essential for uninterrupted production of sperm over long periods of reproductive life span. A better understanding of SSC biology provides limitless opportunities in male reproductive health, fertility preservation, and regenerative medicine. Although several potential markers define SSCs, not many definitive markers exist that are specific for a rare subset of SSCs that self-renew and have the ability to give rise to other progenitors, eventually contributing to all stages of spermatogenesis. In the September 2014 issue of theJCI, Aloisio and colleagues report that PAX7 is a new marker expressed uniquely in a rare subset of SSCs in mouse testes. PAX7+cells fulfill all the criteria required for bona fide SSCs. Surprisingly, male germline-specific deletion ofPax7indicates that it is dispensable for spermatogenesis.