Demands on response inhibition processes determine modulations of theta band activity in superior frontal areas and correlations with pupillometry - Implications for the norepinephrine system during inhibitory control
Demands on response inhibition processes determine modulations of theta band activity in superior frontal areas and correlations with pupillometry - Implications for the norepinephrine system during inhibitory control
复制标题
DOI：
10.1016/j.neuroimage.2017.06.037
复制
发表时间：
2017-08-15
期刊：
影响因子：
5.7
通讯作者：
Beste, Christian
中科院分区：
文献类型：
--
作者：
Dippel, Gabriel;Mueckschel, Moritz;Beste, Christian
反应抑制过程对于目标导向行为是重要的，特别是当它不太可能抑制自动执行的反应时。有人认为，去甲肾上腺素（NE）系统是考虑这种可能性效应的重要因素。作为NE系统活动的间接测量，我们使用瞳孔直径，并将该数据与神经生理学（EEG）数据和波束形成分析相结合。研究表明，θ波振荡反映的抑制性控制过程受到这些过程的强烈调节，这些机制与SMA和SFG中的神经过程有关。可能，观察到的θ波段活动的调制可能反映了意外或冲突信号编码中的调制。有趣的是，对传感器和源水平的神经元活动与瞳孔直径数据的相关性分析显示，只有在很少需要抑制控制过程的情况下才会出现强相关性。根据研究结果和理论模型，瞳孔直径可以被解释为NE系统活性的近似值，结果可以解释为，当抑制阳性反应倾向的可能性较低时，NE系统通过SFB的θ波段活性调节抑制控制过程。由此可以推测，根据决定响应模式的边界条件，NE系统动态地获得和失去与调制抑制控制的相关性。
Response inhibition processes are important for goal-directed behavior and particularly demanded when it is unlikely to inhibit automatically executed responses. It has been suggested that the norepinephrine (NE) system is important to consider for such likelihood effects. As an indirect measure of the NE system activity we used the pupil diameter and integrated this data with neurophysiological (EEG) data and beamforming analyses. The study shows that inhibitory control processes reflected by theta oscillations are strongly modulated by the likelihood to employ these processes and that these mechanisms were related to neural processes in the SMA and SFG. Probably, the modulations observed for theta band activity may reflect modulations in the encoding of a surprise, or conflict signal. Interestingly, correlation analyses of neuronal activity at the sensor and the source level with pupil diameter data revealed strong correlations that were only seen in the condition where inhibitory control processes were rarely demanded. On the basis of findings and theoretical models suggesting that the pupil diameter can be interpreted as a proximate of NE system activity the results may be interpreted that the NE system modulates inhibitory control processes via theta band activity in the SFB when the likelihood to inhibit a prepotent response tendency is low. From this it may be speculated that the NE system dynamically gains and loses relevance to modulate inhibitory control depending on boundary conditions that determine the mode of responding.