Evaluation of skeletal muscle mass in patients with chronic liver disease shows different results based on bioelectric impedance analysis and computed tomography
Evaluation of skeletal muscle mass in patients with chronic liver disease shows different results based on bioelectric impedance analysis and computed tomography
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基于生物电阻抗分析和计算机断层扫描对慢性肝病患者骨骼肌质量的评估显示出不同的结果
DOI：
10.1159/000526563
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
C.
中科院分区：
文献类型：
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作者：
Kikuchi;N.;Uojima;H.;Hidaka;H.;Iwasaki;S.;Wada;N.;Kubota;K.;Nakazawa;T.;Shibuya;A.;Kako;M.;Take;A.;Sakaguchi;Y.;Sato;T.;Kusano;C.
我们的目的是评估之间的差异计算机断层扫描（CT）为基础的和生物电阻抗分析（BIA）为基础的评估肌肉减少症患者慢性肝病（CLD）。肌肉减少症被日本肝病学会定义为骨骼肌质量指数（SMI）低，肌肉力量低。为了评估不同的方法是否影响CLD患者肌肉减少症的诊断，我们评估了使用BIA和CT的低SMI之间不匹配的数量和特征。我们还比较了总生存期（OS），在患者和没有肌肉减少症的基础上CT和BIA，以评估适当的methods.ResultsThe低SMI使用BIA或CT的患者人数分别为53（20.6%）和114（44.3%）例，分别。多变量分析显示，肝腹水和体重是使用BIA与CT的SMI之间不匹配的独立因素（风险比[HR] 3.232，p< 0.001; HR 2.347，p= 0.005）。基于CT的肌肉减少症患者的中位OS显著低于无肌肉减少症患者（p= 0.006）。与此相反，有没有差异的基础上BIA（p= 0.217）。ConclusionMuscle mass in patients with CLD may be overestimated by the BIA method compared to CT when assessing sarcopenia，especially in the cases of fluid retention.
ObjectiveWe aimed to evaluate the difference between computed tomography (CT)-based and bioelectrical impedance analysis (BIA)-based assessment of sarcopenia in patients with chronic liver disease (CLD).MethodsWe enrolled a total of 257 patients who were evaluated with or without sarcopenia. Sarcopenia was defined as a low skeletal muscle mass index (SMI) with low muscular strength by the Japan Society of Hepatology. To evaluate whether or not the different methods influence the diagnosis of sarcopenia for patients with CLD, we assessed the number and characteristics of mismatches between the low SMI using BIA and CT. We also compared the overall survival (OS) in patients with and without sarcopenia based on CT and BIA to evaluate the appropriate methods.ResultsThe numbers of patients with low SMI using BIA or CT were 53 (20.6%) and 114 (44.3%) patients, respectively. Multivariate analysis revealed that hepatic ascites and body weight were independent factors of mismatch between SMI using BIA versus CT (hazard ratio [HR] 3.232, p< 0.001; HR 2.347, p= 0.005, respectively). The median OS in patients with sarcopenia based on CT was significantly lower than that in patients without sarcopenia (p= 0.006). In contrast, there was no difference between patients with sarcopenia based on BIA (p= 0.217).ConclusionMuscle mass in patients with CLD may be overestimated by the BIA method compared to CT when assessing sarcopenia, especially in cases of fluid retention.