Progress in research on miRNA function
Progress in research on miRNA function
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发表时间：
2005
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通讯作者：
Z. Zhuo
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作者：
Z. Zhuo
成熟的miRNA是长度约为20-25个核苷酸的非编码RNA，在植物、无脊椎动物和脊椎动物的基因组中发现了数百种。研究表明，miRNA在基因表达的调节中发挥着重要作用。生物信息学告诉我们，大约1/3的人类基因受到miRNA的调节，提示miRNAs是基因调控网络的核心组成部分，其中一些miRNAs还与人类的某些疾病有关，本文就近年来miRNAs的研究进展作一综述.
Mature miRNAs are noncoding RNAs of about 20-25 nucleotides in length.Hundreds of them have been found in the genomes of plants,invertebrates and vertebrates.The research suggested that the miRNAs play a great role in the regulation of gene expression.Bioinformatics tells us that about 1/3 of total human genes are regulated by the miRNAs,suggesting that the miRNAs are the core component of the gene regulation network.Some of them are also related to some human diseases.The research of miRNA in the recent years is reviewed.