Flow visualization for Nasal Cavity Flow in Aerosol Exhalation Through Nose Treatment
Flow visualization for Nasal Cavity Flow in Aerosol Exhalation Through Nose Treatment
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通过鼻子治疗呼出气溶胶时鼻腔流量的流量可视化
DOI：
10.1007/978-981-10-4220-1_11
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Koichi Tomoda
中科院分区：
文献类型：
--
作者：
Takahisa Yamamoto;Yoshiki Kobayashi;Shunpei Shikano;Masahiro Takeyama;Mikiya Asako;Koichi Tomoda
经鼻药物雾化吸入（ETN）是治疗嗜酸性粒细胞性慢性鼻-鼻窦炎（ECRS）合并哮喘的一种有前途的综合治疗方法。在这种治疗中，患者使用便携式吸入器从口中吸入吸入皮质类固醇（ICS）药物的气雾剂。然后一部分气溶胶仍然漂浮并保留在上气道中。当患者通过鼻子呼出吸入的空气时，气溶胶在中鼻道和嗅裂的壁上被有效地输送。本研究利用计算流体动力学（CFD）方法，对气溶胶药物在呼气过程中的输运现象进行数值模拟，以评价ETN的疗效。CFD分析结果表明，ETN在鼻咽部形成了对上壁的冲击流，并在鼻咽部形成了复杂的旋流和环流。ETN的主要流向为鼻腔上部。这种趋势影响了气溶胶的输送特性，部分气溶胶粒子进入筛窦。
Aerosol medicine exhalation through the nose (ETN) is one of promising and comprehensive treatment methods for Eosinophilic Chronic Rhinosinusitis (ECRS) with asthma. In this treatment, the patient inhales aerosol of inhaled corticosteroid (ICS) medicine from mouth using portable inhaler. Then a part of the aerosol still floats and remains in upper airway. When the patient exhales inhaled air through the nose, the aerosol is effectively transported on the walls of middle meatus and olfactory fissure. This study performed Computational Fluid Dynamics (CFD) analysis for the transport phenomena of aerosol medicine during exhalation period in order to evaluate the curative effect of ETN numerically. As a result of CFD analysis, ETN formed impinging flow toward upper wall of nasopharynx, subsequently complex swirl and circulation flow in the nasopharynx region. In addition, main flow of ETN passed upper region of nasal cavity. Such the tendencies affected on aerosol transport characteristics; a part of aerosol particles moved into ethmoindal sinuses.