Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment
Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment
复制标题
基于网络药理学的草药治疗阿尔茨海默病作用机制研究。
DOI：
10.1016/j.jep.2016.11.034
复制
发表时间：
2017-01-20
影响因子：
5.4
通讯作者：
Wang, Qi
中科院分区：
文献类型：
--
作者：
Fang, Jiansong;Wang, Ling;Wang, Qi
民族药理学相关性：阿尔茨海默病（AD）作为最常见的痴呆症类型，给世界各地的卫生保健系统带来了沉重的经济负担。然而，目前对于AD患者仍然缺乏有效的治疗方法。草药具有多药、多成分、多靶点的特点，在治疗阿尔茨海默病方面积累了大量宝贵的经验，但其确切的分子机制尚不清楚。材料与方法：在本研究中，我们提出了一种基于网络药理学的方法，该方法结合大规模文本挖掘、药物相似性过滤、靶点预测和网络分析来破译研究最广泛的中草药治疗AD的作用机制。结果：PubMed的文本挖掘得到10种与AD有显著相关性的草药。随后，对10种药材进行药物相似性筛选，筛选出1016个化合物，进行结构聚类，总结出药材成分的化学支架。基于AlzhCPI的靶标预测结果，我们构建了化合物靶标（C-T）和靶标通路（T-P）网络来解读抗ad草药的作用机制。结论：该方法为从整体角度探索中药的作用机制提供了新的思路。
Ethnopharmacological relevance: Alzheimer's disease (AD), as the most common type of dementia, has brought a heavy economic burden to healthcare system around the world. However, currently there is still lack of effective treatment for AD patients. Herbal medicines, featured as multiple herbs, ingredients and targets, have accumulated a great deal of valuable experience in treating AD although the exact molecular mechanisms are still unclear.Materials and methods: In this investigation, we proposed a network pharmacology-based method, which combined large-scale text-mining, drug-likeness filtering, target prediction and network analysis to decipher the mechanisms of action for the most widely studied medicinal herbs in AD treatment.Results: The text mining of PubMed resulted in 10 herbs exhibiting significant correlations with AD. Subsequently, after drug-likeness filtering, 1016 compounds were remaining for 10 herbs, followed by structure clustering to sum up chemical scaffolds of herb ingredients. Based on target prediction results performed by our in-house protocol named AlzhCPI, compound-target (C-T) and target-pathway (T-P) networks were constructed to decipher the mechanism of action for anti-AD herbs.Conclusions: Overall, this approach provided a novel strategy to explore the mechanisms of herbal medicine from a holistic perspective.