COMPARATIVE ELECTROPHYSIOLOGIC EVALUATION OF NERVE GRAFTS AND AUTOGENOUS VEIN GRAFTS AS NERVE CONDUITS AN EXPERIMENTAL STUDY
COMPARATIVE ELECTROPHYSIOLOGIC EVALUATION OF NERVE GRAFTS AND AUTOGENOUS VEIN GRAFTS AS NERVE CONDUITS AN EXPERIMENTAL STUDY
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DOI：
10.1055/s-2007-1006936
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发表时间：
1988-01-01
影响因子：
2.1
通讯作者：
KRIZEK T J
中科院分区：
文献类型：
--
作者：
CHIU D T W;LOVELACE R E;KRIZEK T J
本研究的目的是从电生理学角度比较自体静脉移植物与自体神经移植物作为神经再生导管的功效。在两组同等成熟的 Sprague-Dawley 大鼠中切除一段 0.75 厘米的坐骨神经。第一组（31 只大鼠）用自体静脉移植物桥接神经间隙，第二组（24 只大鼠）用自体神经移植物桥接神经间隙。进行了连续体内神经传导速度研究以及终端体外神经传导速度和神经动作电位测量。另外一组 21 只未接受手术的动物也进行了类似的研究，以建立年龄调整的基线进行比较。第一组有 12 只动物，第二组有 14 只动物，基线组有 13 只动物在全年的研究中存活下来。两个实验组之间的体内传导速度比较良好。通过体外技术测定的神经传导速度证实了这一发现，并且测量结果类似，约为基线的 78%。静脉移植组的神经动作电位振幅为基线的 12.0%，而神经移植组为基线的 23.9%。这项研究表明，静脉移植物在神经传导速度方面与神经移植物相当，但在神经动作电位方面只有一半。
This study was carried out to compare electrophysiologically the efficacy of autogenous vein grafts, with autogenous nerve grafts as conduits for nerve regeneration. A 0.75-cm segment of sciatic nerve was resected in two groups of Sprague-Dawley rats of equivalent maturity. The nerve gaps were bridged with an autogenous vein graft in the first group (31 rats), and an autogenous nerve graft in the second group (24 rats). Serial in vivo nerve conduction velocity studies and terminal in vitro nerve conduction velocity and nerve action potential measurements were performed. An additional group of 21 animals who had undergone no surgical procedures, were similarly studied to establish an age-adjusted baseline for comparison. Twelve animals in the first group, 14 in the second group, and 13 in the baseline group survived the full year of study. In vivo conduction velocities between the two experimental groups compared favorably. Nerve conduction velocity determined by in vitro technique confirmed this finding and measured similarly at about 78 percent of the baseline. Nerve action potential amplitude in the vein-grafted group was 12.0 percent of the baseline, while the nerve-grafted group was 23.9 percent of the baseline. This study demonstrated that the vein graft compares well with the nerve graft in nerve conduction velocity, but only one-half as well in nerve action potential.