Long noncoding RNA and its role in virus infection and pathogenesis.
Long noncoding RNA and its role in virus infection and pathogenesis.
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DOI：
10.2741/4750
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发表时间：
2019-03
期刊：
影响因子：
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通讯作者：
Kaining Yi;Yiling Zhang;Yong Wang;Zhilong Wang;Mengjia Xie;Zhigang Jin;T. Zhao
中科院分区：
文献类型：
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作者：
Kaining Yi;Yiling Zhang;Yong Wang;Zhilong Wang;Mengjia Xie;Zhigang Jin;T. Zhao
长链非编码RNA（longnoncodingRNA，lncRNA）是一类长度超过200个核苷酸的RNA分子，在转录和转录后水平调控基因表达。越来越多的证据表明，lncRNA在广泛的生物学过程中发挥重要作用，包括细胞增殖、凋亡和肿瘤发生。病毒感染通常可以调节细胞lncRNA的表达。病毒编码的lncRNA还可以调节宿主基因的表达，这是病毒感染的关键。本文就长链非编码RNA及其与病毒的关系，特别是长链非编码RNA在病毒致肿瘤中的作用作一综述。对lncRNA及其与病毒关系的研究可能为病毒-宿主相互作用及相关疾病的治疗提供新的思路。
Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that regulate gene expression at the transcriptional and post-transcriptional levels. Emerging evidence showed that lncRNAs play important roles in a wide range of biological processes, including cell proliferation, apoptosis, and tumorigenesis. The infection of virus generally can regulate the expression of the cellular lncRNA expression. The lncRNAs which encoded by virus can also modulate the expression of the hosts' gene which is critical for virus infection. Here, we summarized the recent progress on long noncoding RNA and its relationship with virus, especially the function of long noncoding RNA on virus-induced oncogenesis. Studies on lncRNAs and their relationship with viruses may give new insights into virus-host interactions and therapy of related diseases.