Variability of outcome reporting in Hirschsprung's Disease and gastroschisis: a systematic review.
Variability of outcome reporting in Hirschsprung's Disease and gastroschisis: a systematic review.
复制标题
DOI：
10.1038/srep38969
复制
发表时间：
2016-12-12
影响因子：
4.6
通讯作者：
Knight M
中科院分区：
文献类型：
--
作者：
Allin BS;Irvine A;Patni N;Knight M
结果报告的异质性限制了巨结肠病（HD）和胃裂的金标准治疗方法的确定。本综述旨在确定目前在HD和胃裂研究中研究的结果，以便通过为核心结果集（COS）的发展提供信息来应对这种异质性。进行了两次系统评价。如果研究在综述1中比较手术干预作为HD的主要治疗方法，在综述2中比较胃裂则符合纳入的条件。仅以摘要形式提供的研究被排除在报告透明度分析之外。35项HD研究符合纳入本综述的条件，并调查了74项独特的结果。最常见的调查是大便失禁（32项研究，91%）。28项评估研究中有7项（25%）符合透明结果报告的所有标准。30项腹裂研究符合纳入本综述的条件，并调查了62项独特的结果。最常见的调查是住院时间（24项研究，80%）。没有一项被评估的研究符合透明结果报告的所有标准。本综述表明，HD和胃裂的研究结果报告存在异质性和显著的报告偏倚风险。COS的制定可以解决这些问题，并且从审查中制定的结果清单可以在该过程中使用。
Heterogeneity in outcome reporting limits identification of gold-standard treatments for Hirschsprung’s Disease(HD) and gastroschisis. This review aimed to identify which outcomes are currently investigated in HD and gastroschisis research so as to counter this heterogeneity through informing development of a core outcome set(COS). Two systematic reviews were conducted. Studies were eligible for inclusion if they compared surgical interventions for primary treatment of HD in review one, and gastroschisis in review two. Studies available only as abstracts were excluded from analysis of reporting transparency. Thirty-five HD studies were eligible for inclusion in the review, and 74 unique outcomes were investigated. The most commonly investigated was faecal incontinence (32 studies, 91%). Seven of the 28 assessed studies (25%) met all criteria for transparent outcome reporting. Thirty gastroschisis studies were eligible for inclusion in the review, and 62 unique outcomes were investigated. The most commonly investigated was length of stay (24 studies, 80%). None of the assessed studies met all criteria for transparent outcome reporting. This review demonstrates that heterogeneity in outcome reporting and a significant risk of reporting bias exist in HD and gastroschisis research. Development of a COS could counter these problems, and the outcome lists developed from this review could be used in that process.
登录
查看更多内容
影响因子：
1.7
作者：
Kandasamy, Yoga;Whitehall, John;Stalewski, H.
通讯作者：
Stalewski, H.
影响因子：
1.8
作者：
Alali, J. S.;Tander, B.;Klein, M. D.
通讯作者：
Klein, M. D.
影响因子：
1.8
作者：
Gunnarsdottir, A.;Larsson, L. -T.;Arnbjornsson, E.
通讯作者：
Arnbjornsson, E.
影响因子：
2.4
作者：
El-Sawaf, Mohamed;Siddiqui, Sabina;Teitelbaum, Daniel H.
通讯作者：
Teitelbaum, Daniel H.
影响因子：
3.4
作者：
Duncan, N. D.;Plummer, J.;McDonald, A. H.
通讯作者：
McDonald, A. H.