Clonally transmissible cancers in dogs and Tasmanian devils.
Clonally transmissible cancers in dogs and Tasmanian devils.
复制标题
DOI：
10.1038/onc.2009.350
复制
发表时间：
2008-12-01
期刊：
影响因子：
8
通讯作者：
Murchison, E P
中科院分区：
文献类型：
--
作者：
Murchison, E P
袋獾面部肿瘤病（DFTD）和犬传染性性病肿瘤（CTVT）是唯一已知的自然发生的克隆传播的癌症。这些癌症是通过活肿瘤细胞的物理转移传播的，这些肿瘤细胞可以穿过组织相容性屏障移植到无关的宿主中。尽管它们有共同的病因，但DFTD和CTVT是独立进化的，并且具有独特的生活史和宿主适应性。DFTD是一种最近出现的侵袭性面部肿瘤，威胁着塔斯马尼亚魔鬼的灭绝。CTVT是一种通过性传播的肿瘤，在世界范围内分布，可能在数千年前出现。通过对比这两种不寻常的癌症的生物学，分子遗传学和免疫学，我强调了克隆传播的癌症的共同和独特的功能，并讨论了克隆传播的癌症对宿主-病原体进化的影响。
Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. These cancers are transmitted by the physical transfer of viable tumor cells that can be transplanted across histocompatibility barriers into unrelated hosts. Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations. DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction. CTVT is a sexually transmitted tumor of dogs that has a worldwide distribution and that probably arose thousands of years ago. By contrasting the biology, molecular genetics and immunology of these two unusual cancers, I highlight the common and unique features of clonally transmissible cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evolution.