Liposome-anchored mesenchymal stem cells for radiation pneumonia/fibrosis treatment.
Liposome-anchored mesenchymal stem cells for radiation pneumonia/fibrosis treatment.
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DOI：
10.1016/j.biomaterials.2023.122202
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发表时间：
2023-06
期刊：
影响因子：
14
通讯作者：
Hailin Zhou;Yanxiang Zhang;Pei Pei-Pei;Wenhao Shen;Xuan Yi;Kai Yang
中科院分区：
文献类型：
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作者：
Hailin Zhou;Yanxiang Zhang;Pei Pei-Pei;Wenhao Shen;Xuan Yi;Kai Yang
间充质干细胞（mesenchymal stem cells, MSCs）对炎症相关疾病的疗效有限，用于增强MSCs疗效的药物制剂无法大量到达病变组织。本文设计抗氧化脂质体（lipo质体- opc）通过点击化学反应（msc - lipoo - opc）锚定在MSCs膜表面，而不影响MSCs的活力和生理特性，从而使MSCs - lipoo - opc在x射线照射的肺部位有效积累。更重要的是，msc - lipop - opc促进先天免疫细胞（主要包括中性粒细胞、巨噬细胞和treg）数量和极性的改变，有利于抗炎，最终阻止放射性肺纤维化的形成。因此，通过修饰MSCs膜表面载药纳米颗粒，可以提高MSCs和药物对辐射性肺损伤的治疗效果，进一步促进MSCs在辐射损伤和保护中的应用。
The effectiveness of mesenchymal stem cells (MSCs) on inflammation-related disease is limited and the pharmaceutical preparation that was used to enhance the efficacy of MSCs cannot reach the diseased tissue in large quantities. Herein, antioxidant liposome (Lipo-OPC) is designed to anchor onto the surface of MSCs membrane via click chemical reaction (MSC-Lipo-OPC) without affecting the viability and physiological characteristics of MSCs, thus allowing efficient accumulation of MSC-Lipo-OPC in X-ray irradiated lung sites. More importantly, MSC-Lipo-OPC promotes the change of the quantity and polarity of innate immunocytes, mainly including neutrophils, macrophages and Tregs, in favor of anti-inflammatory, finally preventing the formation of radioactive pulmonary fibrosis. Therefore, it could enhance the treatment outcome of both of MSCs and drugs to radiation-induced lung injury via modifying the drug-loaded nanoparticle on the surface of MSCs membrane, further promoting the application of MSCs in radiation damage and protection.