New insights into the mechanism of low high-density lipoprotein cholesterol in obesity.
New insights into the mechanism of low high-density lipoprotein cholesterol in obesity.
复制标题
低高密度脂蛋白胆固醇在肥胖中作用机制的新见解。
DOI：
10.1186/1476-511x-10-176
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发表时间：
2011-10-12
影响因子：
4.5
通讯作者：
Peng DQ
中科院分区：
文献类型：
--
作者：
Wang H;Peng DQ
肥胖是多种慢性疾病的重要危险因素，普遍与以高密度脂蛋白胆固醇（HDL-C）降低为主要表现的血脂异常有关，在心血管疾病（CVD）的发生发展中起着不可或缺的作用。然而，肥胖和低HDL-C的潜在机制尚未完全阐明。以往的研究主要集中在甘油三酯（TG）升高后循环中HDL催化剂的变化。但最近的研究表明，肝脏和脂肪组织在肥胖相关的低HDL-C中起着关键作用。一些新的分子途径如microRNA也被提出来调节肥胖症的HDL代谢。本文就近年来对肥胖症患者低HDL-C发生机制的研究进展作一综述。
Obesity, a significant risk factor for various chronic diseases, is universally related to dyslipidemia mainly represented by decreasing high-density lipoprotein cholesterol (HDL-C), which plays an indispensible role in development of cardiovascular disease (CVD). However, the mechanisms underlying obesity and low HDL-C have not been fully elucidated. Previous studies have focused on the alteration of HDL catabolism in circulation following elevated triglyceride (TG). But recent findings suggested that liver and fat tissue played pivotal role in obesity related low HDL-C. Some new molecular pathways like microRNA have also been proposed in the regulation of HDL metabolism in obesity. This article will review recent advances in understanding of the potential mechanism of low HDL-C in obesity.