Increases in luteinizing hormone are associated with declines in cognitive performance
Increases in luteinizing hormone are associated with declines in cognitive performance
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DOI：
10.1016/j.mce.2006.06.013
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发表时间：
2007-04-15
影响因子：
4.1
通讯作者：
Smith, Mark A.
中科院分区：
文献类型：
--
作者：
Casadesus, Gemma;Milliken, Erin L.;Smith, Mark A.
围绕雌激素治疗绝经后认知能力下降和痴呆的问题，我们研究了绝经后升高的促黄体激素的作用。我们研究了与Y-迷宫任务，在两个品系的转基因小鼠，一个（Tg-LH β）过度表达促黄体生成素和另一个（LHRKO），这增加了循环促黄体生成素水平，但其受体沉默。我们的研究结果表明，Tg-LH β，而不是LHRKO小鼠，显示Y-迷宫性能下降时，与年龄匹配的野生型动物相比。这些发现表明，在功能性受体存在的情况下，促黄体生成激素水平升高可能至少部分地导致绝经后认知能力下降。因此，促黄体生成激素或其受体水平的调节可能被证明是与衰老和年龄相关的神经退行性疾病如阿尔茨海默病相关的认知下降的有用治疗策略。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Questions surrounding estrogen therapy for post-menopausal cognitive decline and dementia led us to examine the role of luteinizing hormone that becomes elevated after menopause. We examined hippocampal-associated cognitive performance, as measured with the Y-maze task, in two strains of transgenic mice, one (Tg-LH beta) which over-expresses luteinizing hormone and another (LHRKO), which has increased circulating luteinizing hormone levels, but its receptors are silenced. Our results demonstrate that Tg-LH beta, but not LHRKO mice, show decreased Y-maze performance when compared to aged-matched wild-type animals. These findings indicate that increased luteinizing hormone levels, in the presence of functional receptors may, at least in part, be responsible for cognitive decline after menopause. As such, modulation of luteinizing hormone or its receptor levels may prove to be useful therapeutic strategies for cognitive decline associated with aging and age-related neurodegenerative diseases such as Alzheimer disease. (c) 2007 Elsevier Ireland Ltd. All rights reserved.