Task-related and item-related brain processes of memory retrieval
Task-related and item-related brain processes of memory retrieval
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DOI：
10.1073/pnas.96.4.1794
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发表时间：
1999-02-16
影响因子：
11.1
通讯作者：
Tulving, E
中科院分区：
文献类型：
--
作者：
Düzel, E;Cabeza, R;Tulving, E
在所有的认知任务中，一般的任务相关过程在给定的任务中对所有的项目都起作用，而特定的项目相关过程在单个项目上的作用是不同的。在典型的功能性神经成像实验中，这两组过程通常被混淆，在此，我们报告了一个联合正电子发射断层扫描和事件相关电位（ERP）实验，旨在区分任务相关和项目相关的记忆提取过程的神经相关。两个检索任务，情景性和语义性，与单个物品的情景性（旧的/新的）和语义性（活的/非活的）属性交叉，以获得与任务相关过程、物品相关过程及其相互作用相关的区域大脑活动的证据。结果表明，情景检索任务与右前额叶和后扣带皮层血流量增加以及持续的右额极阳性ERP相关，而语义检索任务与左额叶和颞叶活动相关。旧物品的检索与左内侧颞叶血流量增加和短暂的晚期ERP阳性成分相关。研究结果为区分任务相关过程和项目相关过程提供了血流动力学和电生理证据，表明它们映射到空间和时间上不同的大脑活动模式，并阐明了前额叶编码和检索不对称的半球编码/检索不对称（HERA）模型。
In all cognitive tasks, general task-related processes operate throughout a given task on all items, whereas specific item-related processes operate differentially on individual items. In typical functional neuroimaging experiments, these two sets of processes have usually been confounded, Herein we report a combined positron emission tomography and event-related potential (ERP) experiment that,vas designed to distinguish between neural correlates of task-related and item-related processes of memory retrieval. Two retrieval tasks, episodic and semantic, were crossed with episodic (old/new) and semantic (living/nonliving) properties of individual items to yield evidence of regional brain activity associated with task-related processes, item-related processes, and their interaction. The results showed that episodic retrieval task was associated with increased blood flow in right prefrontal and posterior cingulate cortex, as well as with a sustained right-frontopolar-positive ERP, but that the semantic retrieval task was associated with left frontal and temporal lobe activity. Retrieval of old items was associated with increased blood flow in the left medial temporal lobe and with a brief late positive ERP component. The results provide converging hemodynamic and electrophysiological evidence for the distinction of task-related and item-related processes, show that they map onto spatially and temporally distinct patterns of brain activity, and clarify the hemispheric encoding/retrieval asymmetry (HERA) model of prefrontal encoding and retrieval asymmetry.