Alcohol-induced changes in the brain as assessed by MRI and CT
Alcohol-induced changes in the brain as assessed by MRI and CT
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DOI：
10.1007/s00330-009-1668-z
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发表时间：
2010-06-01
影响因子：
5.9
通讯作者：
Krings, Timo
中科院分区：
文献类型：
--
作者：
Geibprasert, Sasikhan;Gallucci, Massimo;Krings, Timo
本文综述了结构磁共振成像和计算机断层扫描结果的直接和间接酒精相关的毒性作用对大脑的概述。除了乙醇相关的变化，以大脑，这篇文章还将描述在甲醇和乙二醇中毒的急性设置的成像结果。酒精会导致脑萎缩、渗透性髓鞘溶解、Marchiafava-Bignami病，特别是与营养不良有关时，还可能导致韦尼克脑病。如果停止酗酒，脑萎缩是可以逆转的。如果不治疗，韦尼克脑病可导致昏迷和死亡，早期诊断对于立即开始硫胺素替代治疗很重要。由于临床症状往往是非特异性的，放射科医生在检测酒精滥用及其相关的临床条件中起着重要的作用。
This review provides an overview of structural magnetic resonance imaging and computed tomography findings of direct and indirect alcohol-related toxic effects on the brain. In addition to ethanol-related changes to the brain, this article will also describe imaging findings in the acute setting of methanol and ethylene glycol poisoning. Alcohol will lead to brain atrophy, osmotic myelinolysis, Marchiafava-Bignami disease and, especially when related to malnutrition, may also cause Wernicke encephalopathy. Brain atrophy can be reversible if alcohol abuse is stopped. If not treated, Wernicke encephalopathy can lead to coma and death and an early diagnosis is important for immediate initiation of thiamine substitution. As clinical symptoms are often unspecific, the radiologist plays an important role in the detection of alcohol abuse and its related clinical conditions.