PET/MRI and PET/CT in follow-up of head and neck cancer patients
PET/MRI and PET/CT in follow-up of head and neck cancer patients
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DOI：
10.1007/s00259-014-2707-9
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发表时间：
2014-06-01
影响因子：
9.1
通讯作者：
Veit-Haibach, Patrick
中科院分区：
文献类型：
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作者：
Queiroz, Marcelo A.;Huellner, Martin;Veit-Haibach, Patrick
目的正电子发射断层扫描（PET）/MRI结合了PET的功能和MRI的高软组织对比度。本研究的目的是评估对比增强（ce）PET/MRI与cePET/CT相比，在怀疑复发的头颈癌（HNC）的患者。方法87例患者进行了连续cePET/CT和cePET/MRI使用三模态PET/CT-MRI设置。使用cePET/CT和cePET/MRI评价了复发性HNC检测的诊断准确性。此外，图像质量，存在不明确的F-18-氟脱氧-D-葡萄糖（FDG）的结果不确定的意义和使用钆对比增强的诊断优势进行了analysed.Results cePET/MRI显示没有统计学意义的差异，诊断准确性cePET/CT相比（91.5比90.6%）。两种方法的秘宝品级差不多，只是位置不同。cePET/CT伪影主要位于舌骨上区域，而在cePET/MRI上，伪影更均匀地分布在舌骨上和舌骨下颈部区域。cePET/MRI和cePET/CT显示34个FDG不明确的结果;其中11个通过cePET/MRI可以解决，5个通过cePET/CT可以解决。PET/MRI中使用钆并没有产生更高的诊断准确性，但有助于更好地确定肿瘤边缘的6.9%patient.Conclusion我们的数据表明，cePET/MRI可能是上级相比，cePET/CT，以指定不明确的FDG摄取相关的可能的肿瘤复发后HNC患者随访。这似乎是评价口咽和口腔的首选模式，因为该区域的cePET/CT伪影发生率较高，主要是由于牙科种植体。然而，总体上没有统计学显著差异。
Purpose Positron emission tomography (PET)/MRI combines the functional ability of PET and the high soft tissue contrast of MRI. The aim of this study was to assess contrast-enhanced (ce)PET/MRI compared to cePET/CT in patients with suspected recurrence of head and neck cancer (HNC).Methods Eighty-seven patients underwent sequential cePET/CT and cePET/MRI using a trimodality PET/CT-MRI set-up. Diagnostic accuracy for the detection of recurrent HNC was evaluated using cePET/CT and cePET/MRI. Furthermore, image quality, presence of unclear F-18-fluorodeoxy-D-glucose (FDG) findings of uncertain significance and the diagnostic advantages of use of gadolinium contrast enhancement were analysed.Results cePET/MRI showed no statistically significant difference in diagnostic accuracy compared to cePET/CT (91.5 vs 90.6 %). Artefacts' grade was similar in both methods, but their location was different. cePET/CT artefacts were primarily located in the suprahyoid area, while on cePET/MRI, artefacts were more equally distributed among the supra and infrahyoid neck regions. cePET/MRI and cePET/CT showed 34 unclear FDG findings; of those 11 could be solved by cePET/MRI and 5 by cePET/CT. The use of gadolinium in PET/MRI did not yield higher diagnostic accuracy, but helped to better define tumour margins in 6.9 % of patients.Conclusion Our data suggest that cePET/MRI may be superior compared to cePET/CT to specify unclear FDG uptake related to possible tumour recurrence in follow-up of patients after HNC. It seems to be the modality of choice for the evaluation of the oropharynx and the oral cavity because of a higher incidence of artefacts in cePET/CT in this area mainly due to dental implants. However, overall there is no statistically significant difference.