In vivo mapping of the fast and slow diffusion tensors in human brain
In vivo mapping of the fast and slow diffusion tensors in human brain
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DOI：
10.1002/mrm.10118
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发表时间：
2002-04-01
影响因子：
3.3
通讯作者：
Moseley, ME
中科院分区：
文献类型：
--
作者：
Clark, CA;Hedehus, M;Moseley, ME
最近的研究表明，人脑中的扩散信号衰减是非单指数的，并且可以用分区的水分数来描述。扩散张量成像 (DTI) 可提供有关组织结构和方向的信息，通常使用高达 1000 s mm(-2) 的 b 值，以便信号由快速扩散部分主导。在这项研究中，使用了高达 3500 s mm(-2) 的 b 因子，从而首次能够绘制较慢扩散部分的扩散张量属性。发现慢扩散张量的平均扩散率 (MD) 表现出强烈的白质/灰质 (WM/GM) 对比度。描绘慢张量主方向的地图表明与快张量和 WM 路径的已知方向对齐。 (C) 2002 Wiley-Liss, Inc.
Recent studies have shown that the diffusional signal decay in human brain is non-monoexponential and may be described in terms of compartmentalized water fractions. Diffusion tensor imaging (DTI), which provides information about tissue structure and orientation, typically uses b values up to 1000 s mm(-2) so that the signal is dominated by the fast diffusing fraction. In this study b factors up to 3500 s mm(-2) are utilized, allowing the diffusion tensor properties of the more slowly diffusing fraction to be mapped for the first time. The mean diffusivity (MD) of the slow diffusion tensor was found to exhibit strong white/gray matter (WM/GM) contrast. Maps depicting the principal direction of the slow tensor indicated alignment with the fast tensor and the known orientation of the WM pathways. (C) 2002 Wiley-Liss, Inc.