Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort)
Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort)
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DOI：
10.1161/circulationaha.117.026788
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发表时间：
2017-09-12
期刊：
影响因子：
37.8
通讯作者：
Byrne, Robert A.
中科院分区：
文献类型：
--
作者：
Adriaenssens, Tom;Joner, Michael;Byrne, Robert A.
背景：支架血栓形成(ST)是冠状动脉支架术后的严重并发症。血管内光学相干断层扫描(OCT)可以提供导致ST的机制过程的深入了解。我们进行了一项前瞻性的多中心研究，以评估ST患者的OCT结果。方法：连续的ST患者通过使用中央电话登记系统进行前瞻性登记。在冠状动脉造影证实ST段后，用频域OCT对罪犯血管进行OCT成像。根据标准化方案收集临床数据。华侨城的收购是在一个核心实验室进行分析的。结果：231例ST患者接受了OCT成像；14例(6.1%)的图像质量妨碍了进一步的分析。在其余患者中，62例(28.6%)和155例(71.4%)分别出现早期ST段和晚期/极晚期ST段。支架类型以新一代药物洗脱支架为主，占50.3%。平均参考血管直径2.9±0.6 mm，平均参考血管面积6.8±2.6 mm(2例)。支架扩张不足(支架扩张指数
BACKGROUND: Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST.METHODS: Consecutive patients presenting with ST were prospectively enrolled in a registry by using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed with frequency domain OCT. Clinical data were collected according to a standardized protocol. OCT acquisitions were analyzed at a core laboratory. Dominant and contributing findings were adjudicated by an imaging adjudication committee.RESULTS: Two hundred thirty-one patients presenting with ST underwent OCT imaging; 14 (6.1%) had image quality precluding further analysis. Of the remaining patients, 62 (28.6%) and 155 (71.4%) presented with early and late/very late ST, respectively. The underlying stent type was a new-generation drug-eluting stent in 50.3%. Mean reference vessel diameter was 2.9+/-0.6 mm and mean reference vessel area was 6.8+/-2.6 mm(2). Stent underexpansion (stent expansion index