Partial-volume effect in PET tumor imaging
Partial-volume effect in PET tumor imaging
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DOI：
10.2967/jnumed.106.035774
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发表时间：
2007-06-01
影响因子：
9.3
通讯作者：
Buvat, Irene
中科院分区：
文献类型：
--
作者：
Soret, Marine;Bacharach, Stephen L.;Buvat, Irene
PET具有内在定量的宝贵优势，能够准确测量活体内的示踪剂浓度。在PET肿瘤成像中，表征肿瘤摄取的指标，如标准化摄取值，正变得越来越重要，特别是在监测治疗反应的背景下。然而，当测量小肿瘤的示踪剂摄取时，部分体积效应(PVE)可能会引入较大的偏差。本文的目的是解释什么是PVE，并描述其在PET肿瘤成像中的后果。对PVE所依赖的参数进行了综述。描述了可以采取的措施，以减少可归因于PVE的误差。提出了各种PVE校正方案，并讨论了它们在PET肿瘤成像中的适用性。
PET has the invaluable advantage of being intrinsically quantitative, enabling accurate measurements of tracer concentrations in vivo. In PET tumor imaging, indices characterizing tumor uptake, such as standardized uptake values, are becoming increasingly important, especially in the context of monitoring the response to therapy. However, when tracer uptake in small tumors is measured, large biases can be introduced by the partial-volume effect (PVE). The purposes of this article are to explain what PVE is and to describe its consequences in PET tumor imaging. The parameters on which PVE depends are reviewed. Actions that can be taken to reduce the errors attributable to PVE are described. Various PVE correction schemes are presented, and their applicability to PETtumor imaging is discussed.