Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: a meta-analysis.
Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: a meta-analysis.
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DOI：
10.1186/s12889-016-3083-0
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发表时间：
2016-05-12
影响因子：
4.5
通讯作者：
Kawasaki Y
中科院分区：
文献类型：
--
作者：
Ide K;Yamada H;Kawasaki Y
流感病毒很容易在人与人之间传播，每年的流感流行是全球严重的公共卫生问题。非药物公共卫生干预措施可能有效对抗流感流行，但需要联合干预措施和/或更有效的干预措施。实验研究表明，茶及其成分（特别是儿茶素）具有抗病毒活性。尽管一些临床研究已经调查了使用茶或其成分来预防流感感染，但漱口这些物质的效果仍不确定。我们对随机对照研究和前瞻性队列研究进行了荟萃分析，以评估用茶及其成分漱口对预防流感感染的效果。使用Cochrane图书馆、PubMed/MEDLINE（1966年至2015年9月）、Web of Science（1981年至2015年9月）和Ichu-shi Web（1983年至2015年9月）检索已发表的文献。提取的研究由两名评审员独立阅读，并评估其整体科学质量。符合我们纳入标准的研究在固定效应模型中使用 Mantel-Haenszel 方法进行汇总，并在随机效应模型中进行分析。使用 Akaike 信息准则 (AIC) 和贝叶斯信息准则 (BIC) 评估模型拟合的质量。文献检索和回顾确定了 5 项符合荟萃分析纳入标准的研究（参与者总数，1890 人；平均年龄范围，16-83 岁）。用茶或其成分漱口的参与者比用安慰剂/水漱口或不漱口的参与者表现出较低的流感感染风险（固定效应模型，Mantel-Haenszel方法：相对风险[RR] = 0.70，95%置信区间[CI] = 0.54–0.89；随机效应模型：RR = 0.71， 95% CI = 0.56–0.91）。固定效应模型比随机效应模型具有更好的拟合质量（固定效应模型：AIC = 6.04，BIC = 5.65；随机效应模型：AIC = 8.74，BIC = 7.52）。用茶及其成分漱口可能对流感感染有预防作用。然而，需要对不同人群进行额外的大规模研究并对这些研究进行汇总分析来证实其效果。
Influenza viruses can spread easily from person to person, and annual influenza epidemics are serious public health issues worldwide. Non-pharmaceutical public health interventions could potentially be effective for combatting influenza epidemics, but combined interventions and/or interventions with greater effectiveness are needed. Experimental studies have reported that tea and its ingredients (especially catechins) have antiviral activities. Although several clinical studies have investigated the use of tea or its ingredients to prevent influenza infections, the effect of gargling these substances has remained uncertain. We conducted a meta-analysis of randomized controlled studies and prospective cohort studies to assess the effect of gargling with tea and its ingredients on the prevention of influenza infection. The published literature was searched using the Cochrane Library, PubMed/MEDLINE (1966 to September 2015), Web of Science (1981 to September 2015), and Ichu-shi Web (1983 to September 2015). The extracted studies were read by two reviewers independently, and their overall scientific quality was evaluated. Studies meeting our inclusion criteria were pooled using the Mantel-Haenszel method in a fixed effects model and were also analyzed in a random effects model. The qualities of the model fits were assessed using the Akaike information criterion (AIC) and Bayesian information criterion (BIC). The literature search and review identified 5 studies that met the inclusion criteria for the meta-analysis (total number of participants, 1890; mean age range, 16–83 years). The participants who gargled with tea or its ingredients showed a lower risk of influenza infection than did participants who gargled with placebo/water or who did not gargle (fixed effects model, Mantel-Haenszel method: relative risk [RR] = 0.70, 95 % confidence interval [CI] = 0.54–0.89; random effects model: RR = 0.71, 95 % CI = 0.56–0.91). The fixed effects model had a better quality of fit than the random effects model (fixed effects model: AIC = 6.04, BIC = 5.65; random effects model: AIC = 8.74, BIC = 7.52). Gargling with tea and its ingredients may have a preventative effect for influenza infection. However, additional large-scale studies in different populations and a pooled analysis of these studies are needed to confirm the effect.