On the eve of personalized medicine in oncology.
On the eve of personalized medicine in oncology.
复制标题
DOI：
10.1158/0008-5472.can-08-1374
复制
发表时间：
2008-09-15
期刊：
影响因子：
11.2
通讯作者：
Sullivan D
中科院分区：
文献类型：
--
作者：
Yeatman TJ;Mule J;Dalton WS;Sullivan D
癌症护理和治疗的未来在于“个性化医疗”的概念，这是一种关注个体而不仅仅是疾病的模式。癌症治疗中的个性化药物需要使用分子特征来匹配正确的患者和正确的药物，首先是在临床试验中，然后是在临床实践中。这是一种新的模式，其中信息技术，科学和临床治疗相结合，以改善健康结果和患者满意度。它将需要异常大的数据库，涉及分子和临床数据，以便患者可以主动选择最合适的治疗方法。
The future of cancer care and treatment lies in the concept of ‘‘personalized medicine,’’a model that focuses on the individual, not just the disease. Personalized medicine in cancer care will need to use molecular signatures to match the right patients to the right drugs, first in clinical trials, then in clinical practice. This is a new paradigm in which information technology, science, and clinical treatment are combined to improve health outcomes and patient satisfaction. It will require unusually large databases, relating both molecular and clinical data, such that patients can be proactively selected for the most appropriate therapies.