Polymorphism of the Oxytocin Receptor Gene Modulates Behavioral and Attitudinal Trust among Men but Not Women.
Polymorphism of the Oxytocin Receptor Gene Modulates Behavioral and Attitudinal Trust among Men but Not Women.
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DOI：
10.1371/journal.pone.0137089
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yamagishi T
中科院分区：
文献类型：
--
作者：
Nishina K;Takagishi H;Inoue-Murayama M;Takahashi H;Yamagishi T
催产素受体基因（OXTR）和行为和态度信任之间的关系已经提出，但这种关系的性质尚未确定。我们从470名20-59岁的日本参与者（242名女性）中获得了行为信任数据，以及他们的一般信任水平和人格特质（NEO-FFI）。从这470名参与者中的411名收集唾液颊拭子，并用于OXTR rs 53576的基因分型。我们的参与者被发现有更多的AA等位基因（40%）比GG等位基因（12%）。GG男性比AA男性更信任，态度信任度也更高，当人格特质被控制时，这种差异并没有减少。然而，在妇女中没有观察到这种模式。此外，控制态度信任的男性之间的行为信任的差异降低到一个不显着的水平，但态度信任的差异仍然显着时，行为信任的控制。这些结果表明，OXTR基因型影响态度信任作为一个人的相对稳定的处置的一部分，并通过态度信任的变化进一步影响行为信任。
A relationship between the oxytocin receptor gene (OXTR) and behavioral and attitudinal trust has been suggested, but the nature of this relationship has not yet been established. We obtained behavioral trust data from 470 Japanese participants (242 women) aged 20–59 years, together with their levels of general trust and personality traits (NEO-FFI). Saliva buccal swabs were collected from 411 of these 470 participants and used for genotyping of OXTR rs53576. Our participants were found to have more AA alleles (40%) than GG alleles (12%). The GG men were more trusting and also rated higher on attitudinal trust than AA men, and this difference did not diminish when personality traits were controlled for. However, this pattern was not observed among women. In addition, controlling for attitudinal trust reduced the difference in behavioral trust among men to a non-significant level, but the difference in attitudinal trust remained significant when behavioral trust was controlled. These results indicate that the OXTR genotype affects attitudinal trust as part of an individual’s relatively stable disposition, and further affects behavioral trust through changes in attitudinal trust.