ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells.
ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells.
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ABC1 是吞噬基因 ced-7 的哺乳动物同源物，在吞噬坏死细胞和凋亡细胞过程中是必需的。
DOI：
10.1042/bst0260629
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发表时间：
1998
影响因子：
3.9
通讯作者：
G. Chimini
中科院分区：
文献类型：
--
作者：
A. Moynault;M. Luciani;G. Chimini
吞噬细胞对凋亡小体的快速吞噬在协调正常组织稳态和保护组织免受由于dng细胞的有害释放引起的炎性损伤中是必不可少的[1]。这与暴露于坏死尸体导致的炎症反应形成对比，其清除也是专业吞噬细胞的任务。然而，目前尚不清楚这种二元论是否源于吞噬细胞对坏死或凋亡颗粒的不同识别机制。事实上，更普遍的是，我们对坏死吞噬的调控知之甚少，而不是凋亡吞噬。在秀丽隐杆线虫中，在两个平行途径上工作的几个基因已经被牵连在细胞凋亡死亡的细胞的吞噬过程中，其基础是它们的突变导致尸体的异常持久性[2，3]。其中，ced-5与ced-2和ced-10属于一个独特的途径，已被鉴定为细胞骨架组织者DOCK 180的线虫同源物[4]。Ced-6与ced-1和ced-7一起作为推定的衔接子沿着第二途径起作用;后者最近被鉴定为ATP结合盒（ABC）转运蛋白，其功能尚未阐明[561.
The swift engulfment of apoptotic bodies by phagocytic cells is essential in orchestrating normal tissue homeostasis and in protecting tissues from inflammatory injury due to noxious release from dyng cells [l]. This is in contrast with the inflammatory response that results from exposure to necrotic corpses, whose clearance is also a task of professional phagocytes. It is not known, however, whether this dualism derives from the engagement of different mechanisms of recognition by a phagocyte challenged with a necrotic or apoptotic particle. More generally, in fact, little is known about the regulation of necrotic, as opposed to apoptotic, engulfment. In Caenorhabditis elegans, several genes working on two parallel pathways have been implicated in the process of engulfment of cells dying by apoptosis on the basis that their mutations lead to abnormal persistence of corpses [2, 3]. Among them, ced-5, assigned to a unique pathway with ced-2 and ced-10, has been identified as the nematode homologue of the cytoskeletal organizer DOCK180 [4]. Ced-6 works as a putative adaptor along a second pathway together with ced-1 and ced-7; the latter has been identified recently as an ATP Binding Cassette (ABC) transporter whose function has not yet been elucidated [561.