Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties
Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties
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通过 (+)-5-甲基-10,11-二氢-5H-二苯并[a, d]环庚烯-5, 10-亚胺 (MK-801)（一种具有强效抗惊厥作用的物质）治疗恢复休克抑制行为，中枢拟交感神经和明显的抗焦虑特性
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. A. Totaro
中科院分区：
文献类型：
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作者：
B. Clineschmidt;M. Williams;J. Witoslawski;P. R. Bunting;E. Risley;J. A. Totaro
MK - 801在大鼠中的“反惩罚”和“反冲突”活动通过两个程序进行评估：(1)条件情绪反应（CER）测试，包括不可避免的电击对杠杆按压的抑制；(2)在缺水的动物中进行简单的冲突测试，即因舔水而受到电击。MK - 801在两种方法中的效果在质量上与苯二氮卓类药物相似。在测试前0.5或2小时口服50-400 μg/kg的剂量范围内，MK - 801增加了CER测试中的杠杆按压。在“口渴的大鼠”冲突过程中，如果在测试前2小时或更长时间给予该化合物，则MK - 801的剂量从110 - 1000 μg/kg / o增加电击次数。在研究前1小时给药时，MK - 801无抗冲突活性。
MK‐801 was evaluated in rats for “antipunishment” and “anticonflict” activity in two procedures: (1) A conditioned emotional response (CER) test involving the suppression of lever‐pressing by unaviodable shock and (2) a simple conflict test in water‐deprived animals that were shocked for licking water. The effect of MK‐801 in both procedures was qualitatively similar to the benzodiazepines. Lever‐pressing in the CER test was increased by MK‐801 at doses ranging from 50–400 μg/kg administered orally (p.o.) at either 0.5 or 2 hours prior to testing. The number of shocks received in the “thirsty rat” conflict procedure was increased by MK‐801 at doses from 110–1,000 μg/kg p.o., providing the compound was given 2 or more hours before test. MK‐801 was without anticonflict activity when administered 1 hour prior to study.