MUSCLE ENDURANCE, CANCER-RELATED FATIGUE, AND RADIOTHERAPY IN PROSTATE CANCER SURVIVORS
MUSCLE ENDURANCE, CANCER-RELATED FATIGUE, AND RADIOTHERAPY IN PROSTATE CANCER SURVIVORS
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DOI：
10.1002/mus.21913
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发表时间：
2011-03-01
期刊：
影响因子：
3.4
通讯作者：
Ng, Alexander V.
中科院分区：
文献类型：
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作者：
Alt, Carlynn A.;Gore, Elizabeth M.;Ng, Alexander V.
简介：在这项研究中，我们调查了接受放疗（AT）的前列腺癌幸存者（CS）的肌肉和癌症相关性疲劳（CRF）。研究方法：在13名CS和12名对照组中，通过Piper疲劳量表（PFS）、埃普沃思嗜睡量表-抑郁子量表（CES-D）、体力活动（加速度计）和血红蛋白水平（Hb）评估CAF。肌肉测量包括强度、激活、收缩特性和间歇性背屈期间的耐力。在CS中AT 6周之前和之后进行测试。结果：RT后，PFS评分仅从CS的初始水平增加，而嗜睡、抑郁或体力活动没有变化。仅CS组Hb降低[平均值（SD）：术前，15（1.1）;术后，14.5（1.1）g/dl; P = 0.04]。CS组耐力下降[平均值（SD）：术前，519（340）s;术后，388（203）s; P = 0.04]，对照组耐力增加[平均值（SD）：术前，616（387）s;术后，753（553）s; P = 0.03]。CS中只有耐力与PFS相关（r =-0.55，P = 0.05）。讨论：AT后肌肉耐力受损，可能导致CS中的CRF。肌肉神经43：415-424，2011
Introduction: In this study we investigated muscle and cancer-related fatigue (CRF) in prostate cancer survivors (CS) undergoing radiotherapy (AT). Methods: In 13 CS and 12 controls, CAF was assessed by the Piper Fatigue Scale (PFS), Epworth Sleepiness Scale-Depression subscale (CES-D), physical activity (accelerometer), and hemoglobin levels (Hb). Muscle measures included strength, activation, contractile properties, and endurance during intermittent dorsiflexion. Testing occurred before and after 6 weeks of AT in CS. Results: After RT, the PFS score increased from initial levels in CS only without changes in sleepiness, depression, or physical activity. Hb decreased in CS only [mean (SD): pre, 15 (1.1); post, 14.5 (1.1) g/dl; P = 0.04]. Endurance decreased in CS [mean (SD): pre, 519 (340) s; post, 388 (203) s; P = 0.04] and increased in controls [mean (SD): pre, 616 (387) s; post, 753 (553) s; P = 0.03]. Only endurance was associated with PFS in CS (r = -0.55, P = 0.05). Discussion: Muscle endurance is impaired after AT and may contribute to CRF in CS. Muscle Nerve 43: 415-424, 2011