Merkel cell carcinoma and HIV infection
Merkel cell carcinoma and HIV infection
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DOI：
10.1016/s0140-6736(02)07668-7
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发表时间：
2002-02-09
期刊：
影响因子：
168.9
通讯作者：
Miller, RW
中科院分区：
文献类型：
--
作者：
Engels, EA;Frisch, M;Miller, RW
默克尔细胞癌(MCC)是一种罕见的皮肤癌，多发生在器官移植或B细胞恶性肿瘤后，即免疫抑制或紊乱的条件下。为了进一步评估免疫抑制是否会增加MCC风险，我们通过关联的艾滋病和癌症登记，研究了309 365名获得性免疫缺陷综合征(AIDS)患者的发病情况。我们确定了6例MCC，与普通人群相比，相对危险度为13.4(95%可信区间4.9-29.1)。这些结果表明，人类免疫缺陷病毒诱导的免疫抑制增加了MCC的风险。
Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity. To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309 365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We identified six cases of MCC, corresponding to a relative risk of 13.4 (95% CI 4.9-29.1) compared with the general population. These results suggest that immune suppression induced by the human immunodeficiency virus increases MCC risk.