TUBERCULOSIS OF RABBITS INDUCED BY DROPLET NUCLEI INFECTION .1. INITIAL RESPONSE TO INFECTION
TUBERCULOSIS OF RABBITS INDUCED BY DROPLET NUCLEI INFECTION .1. INITIAL RESPONSE TO INFECTION
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DOI：
10.1084/jem.87.6.575
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发表时间：
1948-01-01
影响因子：
15.3
通讯作者：
WELLS, WF
中科院分区：
文献类型：
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作者：
RATCLIFFE, HL;WELLS, WF
用已知数量的牛结核杆菌强毒液滴，在感染后1 ~> 100天内处死家兔进行检测。沉积在肺的肺泡壁上的分离的杆菌被肺泡巨噬细胞摄取，并且似乎在这些细胞中进行性生长，而不会对它们造成明显的损伤，持续约2周。显然，受感染的细胞保持局部化，再感染的肺泡巨噬细胞在它们周围积聚，最终也被感染。间隔约2周后，感染点周围出现炎症反应，并开始形成结节。结核的进行性发展和这些病变中的杆菌的生长遵循高度一致的速率和模式，直到大约第4周末或第5周末开始时，结核进行干酪化。因此，正常家兔的肺与吸入分离细胞的强毒牛结核杆菌之间的反应可以说是均匀的，持续约4周。此后，这种反应变得不均匀，疾病的进一步进展因动物而异。它的结论是，所证明的感染的均相，兔没有不同的抗牛结核杆菌的初始生长。然而，后来，异质模式的反应，这种感染表明，这些动物的能力差异很大，获得阻力。
Normal rabbits were caused to inhalc known numbers of virulent bovine tubercle bacilli as separated cells in droplet nuclei, and killed for examination from 1 to > 100 days after infection. Separated bacilli, deposited upon alveolar walls of the lungs, were ingested by alveolar macrophages and seemed to grow progressively in these cells without causing obvious damage to them for about 2 weeks. Apparently, infected cells remained localized and reinfected alveolar macrophages accumulated about them, eventually also becoming infected. After an interval of about 2 weeks, inflammatory reactions developed about the points of infection and tubercle formation began. Progressive development of the tubercles and growth of the bacilli in these lesions followed highly uniform rate and pattern until about the end of the 4th week or beginning of the 5th week when tubercles underwent caseation. Thus the reaction between the lungs of normal rabbits and virulent bovine tubercle bacilli inhalcd as separated cells may be said to be homogeneous for about 4 weeks. Thereafter, this reaction became heterogeneous, further progress of the disease varying with the animal. It is concluded that, as evidenced by the homogeneous phase of infection, rabbits do not differ in their resistance to initial growth of bovine tubercle bacilli. However, the later, heterogeneous pattern of response to this infection suggests that these animals vary widely in their capacity to acquire resistance.