Is gastric sham feeding really sham feeding?
Is gastric sham feeding really sham feeding?
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胃假喂养真的是假喂养吗？
DOI：
10.1152/ajpregu.1985.248.3.r387
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Nissenbaum,JW
中科院分区：
文献类型：
--
作者：
Sclafani,A;Nissenbaum,JW
大鼠安装胃插管，禁食，并允许饮用从打开的插管中流出的糖溶液；也就是说，老鼠是假装喂食的。虽然这一过程被认为是为了防止摄入食物的吸收，但研究发现，假性喂养32%的葡萄糖或蔗糖溶液会显著提高血糖水平。在32%的蔗糖溶液中加入阿卡波糖（一种抑制蔗糖消化的药物），就像用可充气的幽门袖关闭幽门一样，可以阻止血糖上升。然而，药物和袖带都没有减少蔗糖溶液的消耗量。这些研究结果表明，胃假喂养并不一定会阻止食物的消化和吸收，尽管吸收对于出现剧烈的假喂养反应并不是必不可少的。然而，不能排除来自胃的神经或激素反馈有助于假喂养反应的可能性，在这个问题得到解决之前，应该谨慎解释胃假喂养研究的结果。
Rats were fitted with gastric cannulas, food deprived, and allowed to drink a sugar solution that drained out of the opened cannula; i.e., the rats sham-fed. Although this procedure is thought to prevent absorption of ingested food, it was found that the sham feeding of a 32% glucose or sucrose solution significantly elevated blood glucose levels. The addition of acarbose, a drug that inhibits the digestion of sucrose, to the 32% sucrose solution blocked the blood glucose rise, as did closing the pylorus with an inflatable pyloric cuff. Neither the drug nor the cuff, however, reduced the amount of sucrose solution consumed. These findings indicate that gastric sham feeding does not necessarily prevent the digestion and absorption of food, although absorption is not essential for the appearance of a vigorous sham-feeding response. Nevertheless the possibility that neural or hormonal feedback from the stomach contributes to the sham-feeding response cannot be excluded, and until this issue is resolved the results of gastric sham-feeding studies should be interpreted with caution.