Encoding of mechanical nociception differs in the adult and infant brain.
Encoding of mechanical nociception differs in the adult and infant brain.
复制标题
机械伤心吸引力的编码在成年和婴儿大脑中有所不同。
DOI：
10.1038/srep28642
复制
发表时间：
2016-06-27
影响因子：
4.6
通讯作者：
Fitzgerald M
中科院分区：
文献类型：
--
作者：
Fabrizi L;Verriotis M;Williams G;Lee A;Meek J;Olhede S;Fitzgerald M
新生儿在受到伤害性皮肤刺激后表现出强烈的疼痛行为和特定的皮质活动，但尚不清楚婴儿和成年人对伤害信息的大脑处理是否有所不同。成像研究强调了婴儿和成人大脑连接体结构的重叠，但对婴儿大脑伤害性网络的电生理学分析可以进一步了解出生后痛觉的功能性发展。这里我们假设，与成年人相比，人类婴儿的大脑以不同的神经元模式编码有害信息。为了测试这一点，我们比较了0-19天的婴儿(n = 18，临床需要)和23-48岁的成年人(n = 21)对相同时间锁定的有毒皮肤长枪的脑电反应。时频分析显示，虽然成人伤害性网络活动的某些特征在婴儿中存在较长的潜伏期，包括β-伽马振荡，但婴儿在快速增量频段(2-4 Hz)上显示出明显的、长潜伏期的、有害的诱发能量增加18倍，这是成年人所没有的。婴儿和成年人之间的活动差异在大脑中具有广泛的地形图分布。这些数据支持我们的假设，并表明人类大脑中机械性疼痛的编码在出生后发生了重要变化。
Newborn human infants display robust pain behaviour and specific cortical activity following noxious skin stimulation, but it is not known whether brain processing of nociceptive information differs in infants and adults. Imaging studies have emphasised the overlap between infant and adult brain connectome architecture, but electrophysiological analysis of infant brain nociceptive networks can provide further understanding of the functional postnatal development of pain perception. Here we hypothesise that the human infant brain encodes noxious information with different neuronal patterns compared to adults. To test this we compared EEG responses to the same time-locked noxious skin lance in infants aged 0–19 days (n = 18, clinically required) and adults aged 23–48 years (n = 21). Time-frequency analysis revealed that while some features of adult nociceptive network activity are present in infants at longer latencies, including beta-gamma oscillations, infants display a distinct, long latency, noxious evoked 18-fold energy increase in the fast delta band (2–4 Hz) that is absent in adults. The differences in activity between infants and adults have a widespread topographic distribution across the brain. These data support our hypothesis and indicate important postnatal changes in the encoding of mechanical pain in the human brain.