Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis
Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis
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DOI：
10.1136/oem.2011.064899
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发表时间：
2012-02-01
影响因子：
4.9
通讯作者：
Lan, Yajia
中科院分区：
文献类型：
--
作者：
Deng, Qian;Wang, Xiaorong;Lan, Yajia
目的描述温石棉接触工人的死亡率，通过对不同模型的拟合和比较，确定石棉接触与肺癌和石棉肺死亡之间的暴露-反应关系。一份结构化的问卷被用来收集个人信息和暴露数据。在车间测量的成对浓度样本被用来将粉尘浓度转换为纤维浓度。个人累积石棉暴露量估计为每项工作中纤维浓度和工作时间的乘积，并以纤维年数/毫升表示。每年对队列成员的生命状况进行跟踪。结果35年随访226例(每1000人年死亡14.6例)，肺癌51例(每1000人年死亡3.29例)，石棉肺37例(每1000人年死亡2.39例)。与肺癌或石棉肺显著的暴露-反应关系(p
Objectives To describe mortality in workers exposed to chrysotile asbestos, and determine exposure-response relationships between asbestos exposure and mortality from lung cancer and asbestosis by fitting and comparing different models.Methods A prospective cohort consisting of 586 workers in an asbestos textile factory was followed from 1 January 1972 to 31 December 2006. A structured questionnaire was administered to collect personal information and exposure data. Paired concentration samples measured in the workshops were used to convert dust concentrations to fibre concentrations. Individual cumulative asbestos exposure was estimated as the product of fibre concentrations and duration of employment in each job and expressed as fibre-years/ml. The vital status of cohort members was followed annually. Poisson regression analysis was applied to fit log-linear, log-quadratic, power, additive relative risk and categorical models to estimate exposure-response relationships between cumulative fibre exposure and mortality from lung cancer and asbestosis.Results Of the 226 deaths (14.6 per 1000 person-years) over the 35-year follow-up, 51 were from lung cancer (3.29 per 1000 person-years) and 37 from asbestosis (2.39 per 1000 person-years). A significant exposure-response relationships with either lung cancer or asbestosis (p