Lipid-rich carcinomas of the mammary gland in seven dogs:: Clinicopathologic and immunohistochemical features
Lipid-rich carcinomas of the mammary gland in seven dogs:: Clinicopathologic and immunohistochemical features
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DOI：
10.1354/vp.40-6-718
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发表时间：
2003-11-01
影响因子：
2.4
通讯作者：
de las Mulas, JM
中科院分区：
文献类型：
--
作者：
de los Monteros, AE;Hellmén, E;de las Mulas, JM
富含脂肪的癌症发生在7只母狗身上。受影响的狗都是纯种的(除一只外)，完好无损(除一只外)，年龄在4到13岁之间。其中5人有产生史，1人有假孕，没有人接受过避孕类固醇。肿瘤为单发(5例)或多发(2例)边界清楚的肿块，大小不一(直径1~6 cm)，由实性的瘤细胞巢和索组成，中间有中等数量的间质。肿瘤细胞含有多个小的或大的孤立的空泡，这些空泡将细胞核推到细胞的外围(印戒细胞)。大多数肿瘤细胞呈腺上皮免疫表型(细胞角蛋白5、8和8、18)。所有肿瘤都缺乏雌激素和孕激素受体，七分之五的肿瘤会导致局部复发和/或远处转移，或者两者兼而有之。
Lipid-rich carcinomas occurred in seven female dogs. Affected dogs were purebred (all but one), intact (all but one), and between 4 and 13 years of age. Five of them had a history of parity, one had pseudopregnancy, and none had received contraceptive steroids. The tumors were single (five cases) or multiple (two cases) well-circumscribed masses of different sizes (varying from I to 6 cm in diameter), composed of solid nests and cords of tumor cells separated by a moderate amount of stroma. The tumor cells contained either multiple and small or large and solitary vacuoles that pushed the nucleus to the periphery of the cell (signet-ring cell). A glandular epithelial immunophenotype (cytokeratins 5 and 8 and 8 and 18) was observed in the majority of tumor cells. All tumors lacked both estrogen and progesterone receptors, and five out of seven tumors gave rise to local recurrence and proximal or distant metastases or both.