KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods.
KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods.
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DOI：
10.1186/s12882-016-0248-0
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发表时间：
2016-03-25
期刊：
影响因子：
2.3
通讯作者：
Ha IS
中科院分区：
文献类型：
--
作者：
Kang HG;Choi HJ;Han KH;Kim SH;Cho HY;Cho MH;Shin JI;Lee JH;Lee J;Oh KH;Park YS;Cheong HI;Ahn C;Ha IS
慢性肾脏病（CKD）的全球患病率正在增加。在儿童中，CKD表现出独特的病因，并可能对儿童的生长和发育产生严重影响。因此，预防CKD及其并发症进展的积极方法势在必行。为了提高对亚洲儿童CKD患者的理解和管理，我们设计并启动了KNOW-Ped CKD（儿童慢性肾病患者结局的韩国队列研究），这是一项由韩国政府资助的全国性、前瞻性和观察性儿童CKD队列研究。从七个主要中心招募了450名年龄<20岁的CKD I至V期患者，以全面评估临床结果、结构化随访和生物标本收集。主要终点包括CKD进展，定义为估计的肾小球滤过率下降50%，需要肾脏替代治疗或死亡。次要结局包括左心室肥大或高血压的发展、生长障碍、神经心理状态、行为状态、肾脏生长和生活质量。通过这项研究，我们希望获得更多关于儿童CKD的信息，这些信息可以转化为更好的患者管理。NCT 02165878（ClinicalTrials.gov），提交日期：2014年6月11日。
The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children’s growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government. From seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life. With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients. NCT02165878 (ClinicalTrials.gov), submitted on June 11, 2014.