Model for the action of hemoglobin.
Model for the action of hemoglobin.
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血红蛋白作用模型。
DOI：
10.1073/pnas.67.4.1662
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发表时间：
1970
影响因子：
11.1
通讯作者：
H. Saroff
中科院分区：
文献类型：
--
作者：
H. Saroff
建立了一个血红蛋白的模型，该模型依赖于血红蛋白的六个四聚体的玻尔群。假设这六个基团位于血红蛋白的四个亚基之间的六个区域中。当玻尔群被假定以不对称的方式扰动结合氧时，这些群就产生了血红蛋白的协同相互作用。这种方法可以解释氧结合，玻尔效应，特定的盐效应，并在一个统一的方式聚集效应。
A model is developed for hemoglobin which depends on six Bohr groups per tetramer of hemoglobin. These six groups are assumed to be located in six regions between the four subunits of hemoglobin. When the Bohr groups are assumed to be perturbed in an asymmetrical manner on binding oxygen, these groups then generate the cooperative interactions of hemoglobin. This approach makes it possible to explain oxygen binding, the Bohr effect, specific salt effects, and aggregation effects in a unified manner.