Inhibition of HIV fusion with multivalent gold nanoparticles
Inhibition of HIV fusion with multivalent gold nanoparticles
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DOI：
10.1021/ja710321g
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发表时间：
2008-06-04
影响因子：
15
通讯作者：
Melander, Christian
中科院分区：
文献类型：
--
作者：
Bowman, Mary-Catherine;Ballard, T. Eric;Melander, Christian
The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. eSDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721) -gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.
