Role of tumor microenvironment in the efficacy of BCG therapy.
Role of tumor microenvironment in the efficacy of BCG therapy.
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肿瘤微环境在BCG治疗功效中的作用。
DOI：
10.15761/tr.1000170
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Kalinski P
中科院分区：
文献类型：
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作者：
Ibrahim OM;Pandey RK;Chatta G;Kalinski P
尽管其显著的总体疗效，BCG未能使相当大比例的膀胱癌（BlCa）患者受益。在这里，我们回顾了最近的数据，突出了肿瘤微环境（TME）在限制BCG治疗的抗肿瘤活性中的作用，以及靶向TME以提高BCG治疗的BlCa患者的总体结局的新机会。
Despite its significant overall efficacy, BCG fails to benefit a substantial proportion of bladder cancer (BlCa) patients. Here, we review recent data highlighting the role of tumor microenvironment (TME) in limiting antitumoral activity of BCG treatment and emerging opportunities to target TME to enhance the overall outcomes in BCG-treated BlCa patients.