Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients.
Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients.
复制标题
血清瓜氨酸纤维蛋白原浓度的变化与菌血症患者的阶段相关。
DOI：
10.1016/j.cca.2020.10.038
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Okumura N.
中科院分区：
文献类型：
--
作者：
Fujimura S;Higuchi Y;Usami Y;Yamaura M;Higuchi T;Terasawa F;Okumura N.
背景瓜氨酸纤维蛋白原（C-Fbg）在类风湿关节炎中已被检测到，但在其他炎症性疾病中的作用研究较少。本研究旨在阐明与菌血症相关联的血清C-Fbg的变化。根据白色细胞（WBC）计数和中性粒细胞左移改变，将菌血症各期的C-Fbg水平与健康对照组（HC）进行比较。评估C-Fbg浓度与某些炎症标志物或瓜氨酸化组蛋白H3浓度之间的相关性。结果菌血症患者血清C-Fbg水平明显高于HC患者（P< 0.001），且与WBC、中性粒细胞计数呈正相关。此外，菌血症III期和IV期的C-Fbg水平显著高于HC（p< 0.001）。MLR分析表明log C-Fbg与log中性粒细胞计数的相关性强于其他某些炎症标志物（p< 0.01）。结论菌血症患者血清C-Fbg水平升高，这与中性粒细胞根据菌血症阶段流入血流相一致。
BackgroundCitrullinated fibrinogen (C-Fbg) has been detected in rheumatoid arthritis; however, few studies have reported the role of C-Fbg in other inflammatory diseases. This study aimed to clarify the changes in serum C-Fbg associated with the bacteremia phase.MethodsWe measured serum C-Fbg concentration in bacteremia patients. C-Fbg levels at each phase of bacteremia, classified by white blood cell (WBC) count and neutrophil left shift change, were compared with those of healthy control (HC). The correlation between C-Fbg concentration and certain inflammatory markers, or citrullinated histone H3 concentration was assessed. Multiple linear regression (MLR) analysis was used to examine the association of log C-Fbg with certain inflammatory markers.ResultSerum C-Fbg levels were significantly higher in bacteremia patients than in HC (p< 0.001) and positively correlated with WBC and neutrophil count. Further, C-Fbg levels were significantly higher in phases III and IV of bacteremia than in HC (p< 0.001). MLR analysis indicated that log C-Fbg had a stronger relationship with log neutrophil counts than other certain inflammatory markers (p< 0.01).ConclusionSerum C-Fbg levels increased in bacteremia patients, and this was consistent with an influx of neutrophils into the blood stream in accordance with the bacteremia phase.
DOI：
10.1016/j.bbrc.2004.11.152
发表时间：
2005-02-04
影响因子：
3.1
作者：
Nakayama-Hamada, M;Suzuki, A;Yamamoto, K
通讯作者：
Yamamoto, K
影响因子：
27.4
作者：
Takizawa, Y.;Suzuki, A.;Yamamoto, K.
通讯作者：
Yamamoto, K.
影响因子：
2.1
作者：
Matsuda, M;Sugo, T
通讯作者：
Sugo, T