Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1
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DOI：
10.1016/j.clim.2009.06.008
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发表时间：
2009-10-01
影响因子：
8.6
通讯作者：
Whitehead, Alexander S.
中科院分区：
文献类型：
--
作者：
Hammons, Andrea L.;Summers, Carolyn M.;Whitehead, Alexander S.
单核细胞趋化蛋白-1(MCP-1)是一种趋化因子，在动脉粥样硬化病变中将单核细胞招募到内皮下细胞层。同型半胱氨酸升高(高同型半胱氨酸血症)通常与低叶酸状态有关，是许多炎症性疾病的已知危险因素。本研究旨在探讨单核细胞趋化蛋白-1(MCP-1)浓度与健康青年叶酸/同型半胱氨酸(Hcy)表型及亚甲基四氢叶酸还原酶(MTHFR)677C和GT；T基因的相关性。在女性中，MCP-1浓度与Hcy呈正相关，与血清和红细胞叶酸呈负相关，女性吸烟者和MTHFR 677T携带者MCP-1浓度升高尤为明显。类似的关系在配偶中看不到。这些发现可能有助于理解女性在一系列自身免疫性疾病中的优势，如系统性红斑狼疮和类风湿性关节炎。(C)2009年，爱思唯尔公司出版。
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated with low-folate status, is a known risk factor for many pathologies with inflammatory etiologies. The present study was undertaken to examine whether there are associations between MCP-1 concentrations and folate/Hcy phenotype or methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype in healthy young adults. In females, MCP-1 concentrations were positively correlated with Hcy and negatively correlated with both serum and red blood cell folate; female smokers and MTHFR 677T carriers had particularly elevated MCP-1 concentrations. Similar relationships were not seen in mates. These findings may have implications for understanding the female predominance observed for a range of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. (C) 2009 Published by Elsevier Inc.