Control of C-elegans larval development by neuronal expression of a TGF-beta homolog
Control of C-elegans larval development by neuronal expression of a TGF-beta homolog
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DOI：
10.1126/science.274.5291.1389
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发表时间：
1996-11-22
期刊：
影响因子：
56.9
通讯作者：
Riddle, DL
中科院分区：
文献类型：
--
作者：
Ren, PF;Lim, CS;Riddle, DL
秀丽线虫Dauer幼虫是在过度拥挤和食物有限的条件下形成的，专门用于扩散而不生长。Daf-7基因编码转化生长因子-β(TGF-β)超家族成员，是传递环境信号以支持食物丰富的持续发展所必需的。一个DAF-7报告结构在ASI化学感觉神经元中表达。诱导Dauer的信息素抑制daf-7的表达并促进Dauer的形成，而食物重新激活daf-7的表达并促进Dauer状态的恢复。当食物/信息素比例较高时，daf-7mRNA水平在L1幼虫阶段达到峰值，此时承诺进行非达尔发育。
The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made.