Evidence for cyclic AMP-mediated increase of aromatic L-amino acid decarboxylase activity in the striatum and midbrain.
Evidence for cyclic AMP-mediated increase of aromatic L-amino acid decarboxylase activity in the striatum and midbrain.
复制标题
环 AMP 介导的纹状体和中脑芳香族 L-氨基酸脱羧酶活性增加的证据。
DOI：
10.1111/j.1471-4159.1993.tb03525.x
复制
发表时间：
1993
影响因子：
4.7
通讯作者：
Hadjiconstantinou,M
中科院分区：
文献类型：
--
作者：
Young,EA;Neff,NH;Hadjiconstantinou,M
Aromatic L‐amino acid decarboxylase (AAAD) activity of mouse striatum and midbrain increased after an intracerebro‐ventricular injection of either forskolin or 8‐bromo‐cyclic AMP. The increase was transient, peaking between 15 and 30 min and returning to baseline by ˜90 min. The increase of AAAD activity after forskolin was not affected by pretreatment with cycloheximide. Kinetic studies indicated an apparent increase ofVmaxwith little change of theKmfor L‐DOPA or pyridoxal 5′‐phosphate. We conclude that AAAD activity of striatum and midbrain can be modulated by a cyclic AMP‐dependent process.
